Effects of antipsychotic drug administration on antioxidative defense enzymes in male rat kidney
2016
Аутори:
Nikolić-Kokić, AleksandraMijušković, Ana
Tatalović, Nikola
Brkljačić, Jelena
Miler, Marko
Oreščanin Dušić, Zorana
Nikolić, Milan
Milošević, Verica
Blagojević, Duško
Spasić, Mihajlo
Miljević, Čedo
Тип документа:
Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт:
The use of atypical antipsychotic drugs (APD) was reported to be associated with adverse effectson the kidneys. Thus, the aim of this study was to examine whether APD exerted their adverseeffects by interfering with the renal antioxidant defense system. Male 3-mo-old Wistar rats weretreated for 28 d with ziprasidone (ZIP), clozapine (CLO), or sertindole (SER) using a daily doserecommended for antipsychotic drug therapy. The expression and activities of antioxidantenzymes superoxide dismutase (SOD) type 1 and type 2, catalase (CAT), glutathione reductase(GR), and glutathione S-transferases (GSTs) activity were measured in the kidneys. Changes in thekidneys were also evaluated histologically. Ziprasidone, CLO, and SER reduced renal SOD type 1and type 2 activities. Decreased CAT activity was observed only in SER-treated rats. An inhibitionin GR activity and increased activity of GST was found only after treatment with CLO. Histologicalanalysis showed dilatation of proximal tubules in kidneys with all three drugs. In conclusion, dataindicate that redox disturbances may contribute to renal morphologic alterations in proximaltubules in rats treated with all APD.
Напомена:
This is an Accepted Manuscript version of the following article, accepted for publication in Journal of Toxicology and Environmental Health, Part A. Aleksandra Nikolić-Kokić, Ana Mijušković, Nikola Tatalović, Jelena Nestorov, Marko Miler, Zorana Oreščanin-Dušić, Milan Nikolić, Verica Milošević, Duško Blagojević, Mihajlo Spasić & Čedo Miljević (2016) Effects of antipsychotic drug administration on antioxidative defense enzymes in male rat kidney, Journal of Toxicology and Environmental Health, Part A, 79:20, 905-911. http://dx.doi.org/10.1080/15287394.2016.1201706
Related to: https://radar.ibiss.bg.ac.rs/handle/123456789/3900
Кључне речи:
ziprasidone; clozapine; sertindole; proximal tubules dilatationИзвор:
Journal of Toxicology and Environmental Health, Part A: Current Issues, 2016, 79, 20, 905-911Финансирање / пројекти:
DOI: 10.1080/15287394.2016.1201706
ISSN: 1528-7394
PubMed: 27644343