Antimikrobna aktivnost vodeno-etanolnog ekstrakta Valeriana officinalis L.

Abstract

The dried rhizome, roots and stolons of V. officinalis are used to make the herbal drug. Drug is widely used as mild sedative and sleep aid for insomnia, excitability, and exhaustion. It has depressant activity on the central nervous system as well as the spasmolytic and carminative activity. The present study was designed to investigate antimicrobial activity of valerian water-ethanol extract. Antimicrobial activities against 3 fungal and 5 bacterial species were evaluated. Examination of antimicrobial activity of valerian extract showed positive activity of samples on following microorganisms: Trichophyton mentagrophytes, Epidermo-phyton floccosum, Microsporum canis, Escherichia coli, Bacillus subtilis, Proteus mirabilis and Enterobacter sp. Concentration of 10 μl/ml of V.officinalis L. extract was MIC (minimal inhibitory concentration) for B.subtilis and E.coli, while the most resistant ones were mentioned fungal species at 100 μl/ml.

Osušeni rizom, korenovi i stoloni Valeriana officinalis L. predstavljaju polaznu sirovinu u proizvodnji biljne droge. Droga ima široku upotrebu kao blag sedativ kao i u terapiji nesanice, nervne napetosti i iscrpljenosti. Umirujuće deluje na centralni nervni sistem, a dokazano je da deluje i kao spazmolitik, karminativ i hipotenziv. U ovom radu ispitivana je antimikrobna aktivnost vodeno-etanolnog ekstrakta odoljena primenom pet bakterijskih i tri gljivične vrste. Ispitivanja antimikrobne aktivnosti ekstrakta odoljena su pokazala pozitivnu aktivnost uzorka na sledeće mikroorganizme: Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Escherichia coli, Bacillus subtilis, Proteus mirabilis and Enterobacter sp. Koncentracija ekstrakta V.officinalis od 10 μl/ml je inhibirala rast (MIC) B. subtilis i E. coli, dok su najveću otpornost ispoljile pomenute gljivične vrste na koncentraciji od 100 μl/ml.