Cadmium and immunologically-mediated homeostasis of anatomical barrier tissues
2021
Authors:
Popov Aleksandrov, AleksandraMirkov, Ivana
Tucović, Dina
Kulaš, Jelena
Ninkov, Marina
Kataranovski, Milena
Document Type:
Review (Published version)
,
© 2020 Elsevier B.V.
Metadata
Show full item recordAbstract:
Cadmium (Cd) is a toxic heavy metal that when absorbed into the body causes nephrotoxicity and effects in other tissues.Anatomical barrier tissues are tissues that prevent the entry of pathogens and include skin, mucus membranes and the immune system. The adverse effects of Cd-induced immune cell's activity are the most extensively studied in the kidneys and the liver. There are though fewer data relating the effect of this metal on the other tissues, particularly in those in which cells of the immune system form local circuits of tissue defense, maintaining immune-mediated homeostasis. In this work, data on the direct and indirect effects of Cd on anatomical barrier tissue of inner and outer body surfaces (the lungs, gut, reproductive organs, and skin) were summarized.
Keywords:
Barrier tissues; Cadmium; Immune systemSource:
Toxicology Letters, 2021, 337, 38-45Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
DOI: 10.1016/j.toxlet.2020.11.008
ISSN: 0378-4274
PubMed: 33246043