Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced arthritis
Аутори:
Đuretić, JasminaDimitrijević, Mirjana
Stojanović, Marija
Kotur Stevuljević, Jelena
Hamblin, Michael R.
Micov, Ana
Stepanović-Petrović, Radica
Leposavić, Gordana
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
The development of collagen type II (CII)-induced arthritis (CIA), a model of rheumatoid arthritis, in rats housed in cages with bedding composed of Celliant fibres containing ceramic particles, which absorb body heat and re-emit the energy back to the body in the form of infrared radiation (+IRF rats), and those housed in cages with standard wooden shaving bedding (−IRF control rats) was examined. The appearance of the first signs of CIA was postponed, while the disease was milder (judging by the arthritic score, paw volume, and burrowing behaviour) in +IRF compared with −IRF rats. This correlated with a lower magnitude of serum anti-CII IgG antibody levels in +IRF rats, and lower production level of IL-17, the Th17 signature cytokine, in cultures of their paws. This could be partly ascribed to impaired migration of antigen-loaded CD11b + dendritic cells and their positioning within lymph nodes in +IRF rats reflecting diminished lymph node expression of CCL19 /CCL21. Additionally, as confirmed in rats with carrageenan-induced paw inflammation (CIPI), the infrared radiation from Celliant fibres, independently from immunomodulatory effects, exerted anti-inflammatory effects (judging by a shift in pro-inflammatory mediator to anti-inflammatory/immunoregulatory mediator ratio towards the latter in paw cultures) and ameliorated burrowing behaviour in CIA rats.
Кључне речи:
Pain; Rheumatoid arthritisИзвор:
Scientific Reports, 2021, 11, 1, 2882-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200161 (Универзитет у Београду, Фармацеутски факултет) (RS-MESTD-inst-2020-200161)
- Innovation Fund of The Republic of Serbia (voucher 404 to GL via Šlarafija D.O.O.)
DOI: 10.1038/s41598-021-81999-7
ISSN: 2045-2322
PubMed: 33536461
WoS: 000616966000010
Scopus: 2-s2.0-85100436092
URI
internal-pdf://Djuretić et al. - 2021 - Infrared radiation from cage bedding moderates rat inflammatory and autoimmune responses in collagen-induced ar.pdfhttps://doi.org/10.1038/s41598-021-81999-7
https://radar.ibiss.bg.ac.rs/handle/123456789/4145