COVID-19 as milestone for the use of new vaccine types
COVID-19 kao prekretnica za upotrebu novih vrsta vakcina
2020
Document Type:
Article (Published version)
,
© 2020 by the Serbian Nutrition Society
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Show full item recordAbstract:
COVID-19 is an infectious disease caused by SARS-CoV-2 virus which
belongs to the Coronaviridae group. The symptoms of the disease are
primarily present in the form of respiratory syndrome similar to the
symptoms of other respiratory viruses such as influenza virus but also
the very common SARS-CoV-1 and MERS-CoV viruses known from the
recent past. However, based on short clinical experience, it was found
that apart from lungs COVID-19 affects all organ systems with unclear
pathogenesis. Respiratory failure followed by systemic hypoxia and coagulation
disorders is hallmarks of severe pathology. In addition, this
virus belongs to the group of RNA viruses that share common characteristics
with the HIV virus, which makes it very challenging for the therapy
of modern medicine. There is currently controversy around the world
about how to combat this epidemic. In addition to hygienic measures
and measures of safe distance and isolation, there is an intense controversy
about prophylactic vaccines. In this review article, the insight
into all aspects of vaccination and methods for their design based on
technological tools possessed by modern science with special reference
to genetic (DNA, RNA) vaccines is provided, and the question arises of
whether there is a justification of novel technology urgent application
in the event of a COVID-19 pandemic.
Keywords:
COVID-19; VLP; Vaccines; Live attenuated; Vector; DNA; RNASource:
Hrana i ishrana, 2020, 61, 1, 1-18Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
URI
https://radar.ibiss.bg.ac.rs/handle/123456789/4178http://hrana-ishrana.org/wp-content/uploads/2021/03/Broj-2-Vol-61-2020.pdf