Vitamin C biochemistry: From scurvy to COVID-19 treatment
Biohemija vitamina C: Od skorbuta do COVID-19 tretmana
2020
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Authors:
Zakić, TamaraBudnar, Marta
Kalezić, Anđelika
Korać, Aleksandra
Janković, Aleksandra
Korać, Bato
Document Type:
Article (Published version)
,
© 2020 by the Serbian Nutrition Society
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Show full item recordAbstract:
The story of vitamin C (L-ascorbic acid) as an antioxidant and a cofactor
in numerous biochemical reactions is a part of its long history and
it is well known today. However, many questions of its mechanism of
action and the benefits that it has on human health are still emerging.
This applies not only to the recommended doses but also to the route
of its administration. Besides, there are numerous questions about the
therapeutic efficacy of vitamin C in various human (infectious) diseases,
as well as its immune system function and antiviral potential.
The fact that vitamin C can act as a reductant (antioxidant) and a prooxidant
further emphasizes its oxidation-reduction (redox) potential
in real physiological conditions. Today, the question of the intravenous
administration of vitamin C effect in patients with SARS-CoV-2
requires special attention. This review aims to showcase known facts
about vitamin C and its mechanisms of action to better understand
the current new challenges related to vitamin C.
Keywords:
Vitamin C; SARS-CoV-2; COVID- 19; Metabolism; Antioxidant; Mechanism of action; Physiological function; Immune function; Cancer; Common coldSource:
Hrana i ishrana, 2020, 61, 2, 59-70Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200178 (University of Belgrade, Faculty of Biology) (RS-MESTD-inst-2020-200178)
URI
http://hrana-ishrana.org/wp-content/uploads/2021/03/Broj-2-Vol-61-2020-1.pdfhttps://radar.ibiss.bg.ac.rs/handle/123456789/4179