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Complete Freund's adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies.

dc.creatorLazarević, Milica
dc.creatorNikolovski, Neda
dc.creatorStanisavljević, Suzana
dc.creatorDimitrijević, Mirjana
dc.creatorStegnjaić, Goran
dc.creatorKrishnamoorthy, Gurumoorthy
dc.creatorMostarica Stojković, Marija
dc.creatorMiljković, Đorđe
dc.creatorJevtić, Bojan
dc.date.accessioned2021-04-15T11:22:14Z
dc.date.available2022-03-16
dc.date.available2022-03-16
dc.date.issued2021
dc.identifier.issn0165-5728
dc.identifier.urihttps://radar.ibiss.bg.ac.rs/handle/123456789/4200
dc.description.abstractExperimental autoimmune encephalomyelitis (EAE) is classically induced with complete Freund's adjuvant (CFA). The immune response against CFA has a confounding influence on the translational capacity of EAE as a multiple sclerosis model. Here, we compare clinical, cellular and molecular properties between syngeneic spinal cord homogenate (SCH)- and SCH + CFA-immunized Dark Agouti rats. EAE signs were observed earlier and the cumulative clinical score was higher without CFA. Also, a higher number of immune cells infiltrates in the spinal cords was noticed at the peak of EAE without CFA. High spinal cord abundance of CD8+CD11bc+MHC class II+ cells was detected in SCH-immunized rats. Myelin basic protein -specific response can be elicited in the cells from the lymph nodes draining the site of SCH immunization. This CFA-free EAE is a reliable multiple sclerosis model.
dc.publisherElsevier BV
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS//
dc.relationEuropean Research Council starting grant (GAMES; 635617)
dc.relationGerman research foundation (DFG) SFB TR-128 (Project A1)
dc.relationMax Planck Society
dc.relation.isreferencedbyhttps://radar.ibiss.bg.ac.rs/handle/123456789/4193
dc.rightsembargoedAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceJournal of Neuroimmunology
dc.subjectCD4(+) T cells
dc.subjectCD8(+) macrophages
dc.subjectCFA
dc.subjectEAE
dc.titleComplete Freund's adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies.
dc.typearticleen
dc.rights.licenseBY-NC-ND
dcterms.abstractКрисхнамоортхy, Гурумоортхy; Миљковић, Ђорђе; Јевтић, Бојан; Стегњаић, Горан; Ђедовић, Неда; Лазаревић, Милица; Станисављевић, Сузана; Мостарица Стојковић, Марија; Димитријевић, Мирјана;
dc.rights.holder© 2021 Elsevier B.V.
dc.citation.volume354
dc.description.noteThis is the peer reviewed version of the following article: Lazarević M, Djedovic N, Stanisavljević S, Dimitrijević M, Stegnjaić G, Krishnamoorthy G, Mostarica Stojković M, Miljković Đ, Jevtić B. Complete Freund’s adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies. J Neuroimmunol. 2021;354:577547. [http://dx.doi.org/10.1016/j.jneuroim.2021.577547]
dc.identifier.doi10.1016/j.jneuroim.2021.577547
dc.identifier.pmid33765502
dc.identifier.scopus2-s2.0-85103341915
dc.identifier.wos000640525500003
dc.citation.apaLazarević, M., Djedovic, N., Stanisavljević, S., Dimitrijević, M., Stegnjaić, G., Krishnamoorthy, G., et al. (2021). Complete Freund’s adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies. Journal of Neuroimmunology, 354, 577547.
dc.citation.vancouverLazarević M, Djedovic N, Stanisavljević S, Dimitrijević M, Stegnjaić G, Krishnamoorthy G, Mostarica Stojković M, Miljković Đ, Jevtić B. Complete Freund’s adjuvant-free experimental autoimmune encephalomyelitis in Dark Agouti rats is a valuable tool for multiple sclerosis studies. J Neuroimmunol. 2021;354:577547.
dc.citation.spage577547
dc.type.versionacceptedVersion
dc.identifier.fulltexthttps://radar.ibiss.bg.ac.rs/bitstream/id/8383/bitstream_8383.pdf
dc.citation.rankM22


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