A Prospective of Multiple Biopharmaceutical Activities of Procyanidins-Rich Uapaca togoensis Pax Extracts: HPLC-ESI-TOF-MS Coupled with Bioinformatics Analysis
2021
Аутори:
Sinan, Kouadio IbrahimeAktumsek, Abdurrahman
Cádiz-Gurrea, María de la Luz
Leyva-Jiménez, Francisco Javier
Fernández-Ochoa, Álvaro
Segura-Carretero, Antonio
Glamočlija, Jasmina
Soković, Marina
Nenadic, Marija
Zengin, Gokhan
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2021 Wiley-VHCA AG, Zurich, Switzerland
Метаподаци
Приказ свих података о документуАпстракт:
The article reports the chemical composition, antioxidant, six key enzymes inhibitory and antimicrobial
activities of two solvent extracts (water and methanol) of leaves and stem bark of Uapaca togoensis. For chemical composition, methanol extract of stem bark exhibited significant higher total phenolic (129.86 mg GAE/g) and flavanol (10.44 mg CE/g) contents. Methanol extract of leaves and water extract of stem bark showed high flavonoids (20.94 mg RE/g) and phenolic acid (90.40 mg CAE/g) content, respectively. In addition, HPLC-ESI-TOFMS analysis revealed that U. togoensis was rich in procyanidins. The methanol and water extracts of stem bark had overall superior antioxidant activity; however, only methanol extract of stem bark showed higher inhibition of cholinesterase (AChE: 2.57 mg GALAE/g; BChE: 4.69 mg GALAE/g), tyrosinase (69.53 mg KAE/g) and elastase (2.73 mmol CE/g). Potent metal chelating ability was showed by water extract of leaves (18.94 mg EDTAE/g), higher inhibition of amylase was detected for water extracts of leaves (0.94 mmol ACAE/g) and stem bark (0.92 mmol ACAE/g). The tested extracts have shown wide-spectrum antibacterial properties and these effects have shown to be more effective against Aspergillus ochraceus, Penicillium funiculosum, Trichoderma viride, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. The results revealed that the antioxidant, enzyme inhibitory and antimicrobial activities depended on the extraction solvents and the parts of plant. Bioinformatics analysis on the 17 major compounds showed modulation of pathway associated with cancer. In brief, U. togoensis might be valuable as potential source of natural agents for therapeutic application.
Кључне речи:
Uapaca togoensis; Antioxidant agents; Antimicrobial activity; KEGG enrichment analysis; ProcyanidinsИзвор:
Chemistry & Biodiversity, 2021, 18, 8, e2100299-
DOI: 10.1002/cbdv.202100299
ISSN: 1612-1872
PubMed: 34086421