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A Prospective of Multiple Biopharmaceutical Activities of Procyanidins-Rich Uapaca togoensis Pax Extracts: HPLC-ESI-TOF-MS Coupled with Bioinformatics Analysis
dc.creator | Sinan, Kouadio Ibrahime | |
dc.creator | Aktumsek, Abdurrahman | |
dc.creator | Cádiz-Gurrea, María de la Luz | |
dc.creator | Leyva-Jiménez, Francisco Javier | |
dc.creator | Fernández-Ochoa, Álvaro | |
dc.creator | Segura-Carretero, Antonio | |
dc.creator | Glamočlija, Jasmina | |
dc.creator | Soković, Marina | |
dc.creator | Nenadic, Marija | |
dc.creator | Zengin, Gokhan | |
dc.date.accessioned | 2021-09-01T14:00:10Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1612-1872 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/4295 | |
dc.description.abstract | The article reports the chemical composition, antioxidant, six key enzymes inhibitory and antimicrobial activities of two solvent extracts (water and methanol) of leaves and stem bark of Uapaca togoensis. For chemical composition, methanol extract of stem bark exhibited significant higher total phenolic (129.86 mg GAE/g) and flavanol (10.44 mg CE/g) contents. Methanol extract of leaves and water extract of stem bark showed high flavonoids (20.94 mg RE/g) and phenolic acid (90.40 mg CAE/g) content, respectively. In addition, HPLC-ESI-TOFMS analysis revealed that U. togoensis was rich in procyanidins. The methanol and water extracts of stem bark had overall superior antioxidant activity; however, only methanol extract of stem bark showed higher inhibition of cholinesterase (AChE: 2.57 mg GALAE/g; BChE: 4.69 mg GALAE/g), tyrosinase (69.53 mg KAE/g) and elastase (2.73 mmol CE/g). Potent metal chelating ability was showed by water extract of leaves (18.94 mg EDTAE/g), higher inhibition of amylase was detected for water extracts of leaves (0.94 mmol ACAE/g) and stem bark (0.92 mmol ACAE/g). The tested extracts have shown wide-spectrum antibacterial properties and these effects have shown to be more effective against Aspergillus ochraceus, Penicillium funiculosum, Trichoderma viride, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. The results revealed that the antioxidant, enzyme inhibitory and antimicrobial activities depended on the extraction solvents and the parts of plant. Bioinformatics analysis on the 17 major compounds showed modulation of pathway associated with cancer. In brief, U. togoensis might be valuable as potential source of natural agents for therapeutic application. | sr |
dc.language.iso | en | sr |
dc.publisher | Zurich, Switzerland: Wiley-VHCA AG | sr |
dc.rights | restrictedAccess | sr |
dc.source | Chemistry & Biodiversity | sr |
dc.subject | Uapaca togoensis | sr |
dc.subject | Antioxidant agents | sr |
dc.subject | Antimicrobial activity | sr |
dc.subject | KEGG enrichment analysis | sr |
dc.subject | Procyanidins | sr |
dc.title | A Prospective of Multiple Biopharmaceutical Activities of Procyanidins-Rich Uapaca togoensis Pax Extracts: HPLC-ESI-TOF-MS Coupled with Bioinformatics Analysis | sr |
dc.type | article | sr |
dc.rights.license | ARR | sr |
dcterms.abstract | Леyва-Јимéнез, Францисцо Јавиер; Зенгин, Гокхан; Ненадиц, Марија; Соковиц, Марина; Гламоциља, Јасмина; Сегура-Царретеро, Aнтонио; Фернáндез-Оцхоа, Áлваро; Цáдиз-Гурреа, Марíа де ла Луз; Aктумсек, Aбдуррахман; Синан, Коуадио Ибрахиме; | |
dc.rights.holder | © 2021 Wiley-VHCA AG, Zurich, Switzerland | sr |
dc.citation.issue | 8 | |
dc.citation.volume | 18 | |
dc.identifier.doi | 10.1002/cbdv.202100299 | |
dc.identifier.pmid | 34086421 | |
dc.identifier.scopus | 2-s2.0-85108354561 | |
dc.identifier.wos | 000664200700001 | |
dc.citation.apa | Sinan, K. I., Aktumsek, A., Cádiz-Gurrea, M. de la L., Leyva-Jiménez, F. J., Fernández-Ochoa, Á., Segura-Carretero, A., et al. (2021). A Prospective of Multiple Biopharmaceutical Activities of Procyanidins-Rich Uapaca togoensis Pax Extracts: HPLC-ESI-TOF-MS Coupled with Bioinformatics Analysis. Chemistry & Biodiversity, 18(8), e2100299. | |
dc.citation.vancouver | Sinan KI, Aktumsek A, Cádiz-Gurrea M de la L, Leyva-Jiménez FJ, Fernández-Ochoa Á, Segura-Carretero A, Glamocilja J, Sokovic M, Nenadić M, Zengin G. A Prospective of Multiple Biopharmaceutical Activities of Procyanidins-Rich Uapaca togoensis Pax Extracts: HPLC-ESI-TOF-MS Coupled with Bioinformatics Analysis. Chem Biodivers. 2021;18(8):e2100299. | |
dc.citation.spage | e2100299 | |
dc.type.version | publishedVersion | sr |
dc.citation.rank | M22 |