Antibacterial and antibiofilm activity of selected polyphenolic compounds: An in vitro study on Staphylococcus aureus
2020
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Staphylococcus aureus is a human pathogen that causes serious infections with high mortality rates. The antimicrobial activities of eight phenolic compounds (caffeic acid, chlorogenic acid, ferulic acid, morin, quercetin, isoquercitrin, rutin and hesperidin) were evaluated against planktonic and biofilm forming Staphylococcus aureus cells. Their ability to prevent biofilm formation via interference with bacterial cell adhesion and to reduce biomass of 24 h old biofilms has been addressed in this study. The antibacterial activities (MIC/MBC) were demonstrated using the microdilution method and the investigated compounds showed good activity against S. aureus isolates, with MICs in the range 0.05-0.4 mg/mL. Also, they exhibited promising antibiofilm potential in dose depended manner. Among all tested compounds, morin and quercetrin showed the best antibiofilm activity at MIC values. The observed antimicrobial potential of the studied natural products can serve as a starting point towards development of novel plant-based therapeutics for the treatment of common infections such as the ones caused by S. aureus.
Кључне речи:
Antibacterial activity; Phenolic compounds; Staphylococcus aureus; BiofilmИзвор:
Lekovite Sirovine, 2020, 40, 57-61Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)