A Comparative Analysis of the In Vitro Anticancer Activity of Iridium(III) {η 5 -C5Me4R} Complexes with Variable R Groups
2021
Аутори:
De Palo, AliceDrača, Dijana
Murrali, Maria Grazia
Zacchini, Stefano
Pampaloni, Guido
Mijatović, Sanja
Maksimović-Ivanić, Danijela
Marchetti, Fabio
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Piano-stool iridium complexes based on the pentamethylcyclopentadienyl ligand (Cp*)
have been intensively investigated as anticancer drug candidates and hold much promise in this
setting. A systematic study aimed at outlining the effect of Cp* mono-derivatization on the an tiproliferative activity is presented here. Thus, the dinuclear complexes [Ir(η
5
-C5Me4R)Cl(µ-Cl)]2
(R = Me, 1a; R = H, 1b; R = Pr, 1c; R = 4-C6H4F, 1d; R = 4-C6H4OH, 1e), their 2-phenylpyridyl
mononuclear derivatives [Ir(η
5
-C5Me4R)(kN,kCPhPy)Cl] (2a–d), and the dimethylsulfoxide complex
[Ir{η
5
-C5Me4
(4-C6H4OH)}Cl2
(κS-Me2S=O)] (3) were synthesized, structurally characterized, and
assessed for their cytotoxicity towards a panel of six human and rodent cancer cell lines (mouse
melanoma, B16; rat glioma, C6; breast adenocarcinoma, MCF-7; colorectal carcinoma, SW620 and
HCT116; ovarian carcinoma, A2780) and one primary, human fetal lung fibroblast cell line (MRC5).
Complexes 2b (R = H) and 2d (4-C6H4F) emerged as the most active ones and were selected for further
investigation. They did not affect the viability of primary mouse peritoneal cells, and their tumorici dal action arises from the combined influence on cellular proliferation, apoptosis and senescence. The
latter is triggered by mitochondrial failure and production of reactive oxygen and nitrogen species.
Кључне речи:
bioorganometallic chemistry; organoiridium complexes;; cytotoxicity; apoptosis; senescence; cell proliferationИзвор:
International Journal of Molecular Sciences, 2021, 22, 14, 7422-Финансирање / пројекти:
- University of Pisa (PRA_2020_39)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
DOI: 10.3390/ijms22147422
ISSN: 1422-0067
PubMed: 34299041