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Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies.
dc.creator | Monfoulet, Laurent‐Emmanuel | |
dc.creator | Ruskovska, Tatjana | |
dc.creator | Ajdžanović, Vladimir | |
dc.creator | Havlik, Jaroslav | |
dc.creator | Vauzour, David | |
dc.creator | Bayram, Banu | |
dc.creator | Krga, Irena | |
dc.creator | Corral-Jara, Karla-Fabiola | |
dc.creator | Kistanova, Elena | |
dc.creator | Abadjieva, Desislava | |
dc.creator | Massaro, Marika | |
dc.creator | Scoditti, Egeria | |
dc.creator | Deligiannidou, Eirini | |
dc.creator | Kontogiorgis, Christos | |
dc.creator | Arola-Arnal, Anna | |
dc.creator | van Schothorst, Evert M | |
dc.creator | Morand, Christine | |
dc.creator | Milenkovic, Dragan | |
dc.date.accessioned | 2021-10-05T08:13:18Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1613-4125 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/mnfr.202100227 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/34048642 | |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/4437 | |
dc.description.abstract | SCOPE Flavanols are important polyphenols of the human diet with extensive demonstrations of their beneficial effects on cardiometabolic health. They contribute to preserve health acting on a large range of cellular processes. The underlying mechanisms of action of flavanols are not fully understood but involve a nutrigenomic regulation. METHODS AND RESULTS To further capture how the intake of dietary flavanols results in the modulation of gene expression, nutrigenomics data in response to dietary flavanols obtained from animal models of cardiometabolic diseases have been collected and submitted to a bioinformatics analysis. This systematic analysis shows that dietary flavanols modulate a large range of genes mainly involved in endocrine function, fatty acid metabolism, and inflammation. Several regulators of the gene expression have been predicted and include transcription factors, miRNAs and epigenetic factors. CONCLUSION This review highlights the complex and multilevel action of dietary flavanols contributing to their strong potential to preserve cardiometabolic health. The identification of the potential molecular mediators and of the flavanol metabolites driving the nutrigenomic response in the target organs is still a pending question which the answer will contribute to optimize the beneficial health effects of dietary bioactives. | |
dc.publisher | John Wiley and Sons | |
dc.relation | European Cooperation in Science and Technology (COST) FA1403 | |
dc.rights | restrictedAccess | |
dc.source | Molecular Nutrition & Food Research | |
dc.source | Molecular Nutrition & Food Research | |
dc.subject | animal models | |
dc.subject | cardiometabolic health | |
dc.subject | dietary intervention | |
dc.subject | flavanols | |
dc.subject | nutrigenomic | |
dc.title | Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies. | |
dc.type | article | en |
dc.rights.license | ARR | |
dcterms.abstract | Русковска, Татјана; Aјджановић, Владимир; Хавлик, Јарослав; Массаро, Марика; Сцодитти, Егериа; Контогиоргис, Цхристос; Aрола-Aрнал, Aнна; Делигианнидоу, Еирини; ван Сцхотхорст, Еверт М; Миленковиц, Драган; Моранд, Цхристине; Ваузоур, Давид; Крга, Ирена; Кистанова, Елена; Aбадјиева, Десислава; Цоррал-Јара, Карла-Фабиола; Баyрам, Бану; Монфоулет, Лаурент‐Еммануел; | |
dc.rights.holder | © 2021 Wiley-VCH GmbH | |
dc.citation.issue | 16 | |
dc.citation.volume | 65 | |
dc.identifier.doi | 10.1002/mnfr.202100227 | |
dc.identifier.pmid | 34048642 | |
dc.identifier.scopus | 2-s2.0-85109287017 | |
dc.identifier.wos | 000669025100001 | |
dc.citation.apa | Monfoulet, L., Ruskovska, T., Ajdžanović, V., Havlik, J., Vauzour, D., Bayram, B., et al. (2021). Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies. Molecular Nutrition & Food Research, 65(16), e2100227. | |
dc.citation.vancouver | Monfoulet L, Ruskovska T, Ajdžanović V, Havlik J, Vauzour D, Bayram B, Krga I, Corral-Jara K-F, Kistanova E, Abadjieva D, Massaro M, Scoditti E, Deligiannidou E, Kontogiorgis C, Arola-Arnal A, van Schothorst EM, Morand C, Milenkovic D. Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies. Mol Nutr Food Res. 2021;65(16):e2100227. | |
dc.citation.spage | e2100227 | |
dc.type.version | publishedVersion | |
dc.citation.rank | aM21 |