Influence of the addition of different radiopacifiers and bioactive nano-hydroxyapatite on physicochemical and biological properties of calcium silicate based endodontic ceramic
2021
Аутори:
Antonijević, ĐorđeDespotović, Ana
Biočanin, Vladimir
Milošević, Miloš
Trišić, Dijana
Lazović, Vladimir
Zogović, Nevena
Milašin, Jelena
Ilić, Dragan
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2021 Elsevier Ltd and Techna Group S.r.l.
Метаподаци
Приказ свих података о документуАпстракт:
The purpose of this study was to investigate the influence of different radiopacifiers on the physicochemical and biological properties of novel calcium silicate based endodontic ceramic enriched with bioactive nano-particulated hydroxyapatite – ECHA. Namely, ECHA was used as a basis for mixing with the following radiopacifiers: strontium fluoride (SrF2), zirconium dioxide (ZrO2) and bismuth oxide (Bi2O3). For comparison, Portland cement (PC) and mineral trioxide aggregate (MTA) were used. The following physicochemical characteristics were examined: the radiopacity, setting time, compressive strength, porosity, wettability and pH value. The biocompatibility of the cements was assessed by crystal violet, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) and cell adhesion assays. The highest radiopacity was obtained for the ECHA + Bi2O3 mixture and MTA that were statistically significant in comparison to other materials (p < 0.05). Both initial and final setting times as well as compressive strengths were statistically lower for experimental cements than for PC and MTA (p < 0.05). The lowest total porosity was observed in the ECHA + ZrO2 group when compared with the other two experimental cements (p < 0.05), but not when compared with PC and MTA (p > 0.05). Experimental cements exhibited statistically higher contact angles of glycerol than PC and MTA (p < 0.05). For blood plasma, a statistical difference was found only between ECHA + Bi2O3 and PC (p < 0.05). All investigated materials had alkalization ability. Cell viability assays revealed that the extracts of tested cements did not exhibit cytotoxic effect on L929 cells. Scanning electron microscopy had shown a high degree of cell proliferation and adhesion of cells from apical papilla on experimental cements’ surfaces. Novel endodontic ceramics with nano-hydroxyapatite addition have satisfactory biological and physicochemical properties when compared to MTA and PC controls. Considerable lower setting time of experimental cements might present a huge advantage of these synthesized materials in clinical practice. SrF2 presents a novel promising radiopacifying agent for dental cements manufacturing.
Кључне речи:
Bismuth oxide; Endodontic surgery; Hydroxyapatite; Radiopacifier; Strontium fluoride; Zirconium dioxideИзвор:
Ceramics International, 2021, 47, 20, 28913-28923Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
- Ministry of Science and Technology of the People's Republic of China 451-02-818/2021-09/20
Повезане информације:
- Друга верзија
https://radar.ibiss.bg.ac.rs/handle/123456789/4464
DOI: 10.1016/j.ceramint.2021.07.052
ISSN: 0272-8842
WoS: 000694740300001
Scopus: 2-s2.0-85110294216
URI
https://linkinghub.elsevier.com/retrieve/pii/S0272884221020794https://radar.ibiss.bg.ac.rs/handle/123456789/4445