Synthesis, characterization and cytotoxicity evaluation of ni(Ii), cu(ii) and zn(ii) complexes with deoxycholate ligand
2021
Аутори:
Culita, Daniela C.Dyakova, Lora
Marinescu, Gabriela
Zhivkova, Tanya
Georgieva, Milena
Vasileva, Bela
Spasov, Rossen
Miloshev, George
Kalfin, Reni
Vidaković, Melita
Oprea, Ovidiu
Alexandrova, Radostina
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2021, Romanian Society for Pharmaceutical Sciences.
Метаподаци
Приказ свих података о документуАпстракт:
Three new complexes of Ni(II), Cu(II) and Zn(II) with deoxycholate anion, of the type M(DCA)2 · nH2O (M = Cu(II) n = 4, M = Ni(II) n = 3 and M = Zn(II) n = 2) have been synthesized and characterized on the basis of elemental analysis, FTIR and UV-Vis spectroscopy, thermal analysis, molar conductivity and magnetic measurements. The cytotoxicity of the synthesized complexes was tested against HT29 human colorectal cancer cells. Applied at a concentration range of 10-200 µg/mL, sodium deoxycholate and its metal complexes have been found to decrease viability and growth of cultured HT29 cells in a time-and concentration-dependent manner in short-term and long-term experiments. The ability of the complexes to induce pathological changes, genotoxicity and apoptosis in the treated cells has also been proved. In addition, the complexes demonstrated a cytotoxic effect in HT29-OxPt (resistant to oxaliplatin) cells, allowing to conclude that they are more pronounced cytotoxic agents as compared to the sodium deoxycholate alone.
Кључне речи:
Colorectal cancer cells; Cytotoxicity; Deoxycholate complexes; Transition metalsИзвор:
Farmacia, 2021, 69, 3, 446-460Финансирање / пројекти:
- Bulgarian Ministry of Education and Science under the National Research Programme "Young scientists" DFNP-17-89
- European Cooperation in Science and Technology (COST) CA16119
- Bulgarian Ministry of Education and Science KOCT 01-10
DOI: 10.31925/farmacia.2021.3.7
ISSN: 0014-8237
WoS: 000667509000007
Scopus: 2-s2.0-85109980762
URI
https://farmaciajournal.com/issue-articles/synthesis-characterization-and-cytotoxicity-evaluation-of-niii-cuii-and-znii-complexes-with-deoxycholate-ligand/https://radar.ibiss.bg.ac.rs/handle/123456789/4446