Overview of Beneficial Effects of (Poly)phenol Metabolites in the Context of Neurodegenerative Diseases on Model Organisms.
2021
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Authors:
Carregosa, DiogoMota, Sara
Ferreira, Sofia
Alves-Dias, Beatriz
Lončarević-Vasiljković, Nataša
Crespo, Carolina Lage
Menezes, Regina
Teodoro, Rita
Santos, Cláudia Nunes dos
Document Type:
Article (Published version)
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Show full item recordAbstract:
The rise of neurodegenerative diseases in an aging population is an increasing problem of health, social and economic consequences. Epidemiological and intervention studies have demonstrated that diets rich in (poly)phenols can have potent health benefits on cognitive decline and neurodegenerative diseases. Meanwhile, the role of gut microbiota is ever more evident in modulating the catabolism of (poly)phenols to dozens of low molecular weight (poly)phenol metabolites that have been identified in plasma and urine. These metabolites can reach circulation in higher concentrations than parent (poly)phenols and persist for longer periods of time. However, studies addressing their potential brain effects are still lacking. In this review, we will discuss different model organisms that have been used to study how low molecular weight (poly)phenol metabolites affect neuronal related mechanisms gathering critical insight on their potential to tackle the major hallmarks of neurodegeneration.
Keywords:
Caenorhabditis elegans; Drosophila; Saccharomyces cerevisiae; Human; Microbiota; Neurodegeneration; Phytochemicals; Rodents; ZebrafishSource:
Nutrients, 2021, 13, 9, 2940-
DOI: 10.3390/nu13092940
ISSN: 2072-6643
PubMed: 34578818
WoS: 000701070300001
Scopus: 2-s2.0-85113348212
URI
https://www.mdpi.com/2072-6643/13/9/2940http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC8464690
https://radar.ibiss.bg.ac.rs/handle/123456789/4475