Chicory Extracts and Sesquiterpene Lactones Show Potent Activity against Bacterial and Fungal Pathogens.
2021
Аутори:
Häkkinen, Suvi T.Soković, Marina
Nohynek, Liisa
Ćirić, Ana
Ivanov, Marija
Stojković, Dejan
Tsitko, Irina
Matos, Melanie
Baixinho, João P.
Ivasiv, Viktoriya
Fernández, Naiara
Nunes Dos Santos, Claudia
Oksman-Caldentey, Kirsi-Marja
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
Chicory (Cichorium intybus L.) is an important industrial crop cultivated mainly to extract the dietary fiber inulin. However, chicory also contains bioactive compounds such as sesquiterpene lactones and certain polyphenols, which are currently discarded as waste. Plants are an important source of active pharmaceutical ingredients, including novel antimicrobials that are urgently needed due to the global spread of drug-resistant bacteria and fungi. Here, we tested different extracts of chicory for a range of bioactivities, including antimicrobial, antifungal and cytotoxicity assays. Antibacterial and antifungal activities were generally more potent in ethyl acetate extracts compared to water extracts, whereas supercritical fluid extracts showed the broadest range of bioactivities in our assays. Remarkably, the chicory supercritical fluid extract and a purified fraction thereof inhibited both methicillin-resistant Staphylococcus aureus (MRSA) and ampicillin-resistant Pseudomonas aeruginosa IBRS P001. Chicory extracts also showed higher antibiofilm activity against the yeast Candida albicans than standard sesquiterpene lactone compounds. The cytotoxicity of the extracts was generally low. Our results may thus lead to the development of novel antibacterial and antifungal preparations that are both effective and safe for human use.
Кључне речи:
Antifungal; Antimicrobial; Bioactivity; Biofilm; Chicory; CytotoxicityИзвор:
Pharmaceuticals (Basel, Switzerland), 2021, 14, 9, 941-Финансирање / пројекти:
DOI: 10.3390/ph14090941
ISSN: 1424-8247
PubMed: 34577641
WoS: 000701833100001
Scopus: 2-s2.0-85115612214
URI
https://www.mdpi.com/1424-8247/14/9/941http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC8469098
https://radar.ibiss.bg.ac.rs/handle/123456789/4493