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Ibogaine-Mediated ROS/Antioxidant Elevation in Isolated Rat Uterus Is β-Adrenergic Receptors and KATP Channels Mediated
dc.contributor | Taira, Junsei | |
dc.creator | Tatalović, Nikola | |
dc.creator | Vidonja Uzelac, Teodora | |
dc.creator | Oreščanin Dušić, Zorana | |
dc.creator | Nikolić-Kokić, Aleksandra | |
dc.creator | Bresjanac, Mara | |
dc.creator | Blagojević, Duško | |
dc.date.accessioned | 2021-11-22T12:55:22Z | |
dc.date.available | 2021-11-22T12:55:22Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2076-3921 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/4662 | |
dc.description.abstract | Ibogaine effects are mediated by cellular receptors, ATP depletion followed by ROS production and antioxidant enzyme activity elevation in a dose and time dependent manner. Since the role of KATP channels and β -adrenoceptors in ROS cellular circuit was established here we explored their role in ibogaine pro-antioxidant effectiveness. Single dose of ibogaine (10 mg/L i.e., 28.8 µmol/L) was applied to isolated rat uterus (spontaneous and Ca2+-stimulated) and contractility and antioxidant enzymes activity were monitored during 4 h. Ibogaine increased amplitude and frequency of spontaneous active uteri immediately after addition that was prevented by propranolol ( 1 and 2 adrenoceptors selective antagonists) and glibenclamide (KATP sensitive channels inhibitor; only frequency) pre-treatment. In Ca2+-stimulated uteri, ibogaine decreased both amplitude and frequency after 4 h. Pre-treatment with propranolol abolished ibogaine induced amplitude lowering, while glibenclamide had no effect. In both types of active uterus, ibogaine induced a decrease in SOD1 and an increase in CAT activity after 2 h. In Ca2+-stimulated uterus, there was also a decrease of SOD2 activity after 2 h. After 4 h, SOD1 activity returned to the baseline level, but GSH-Px activity increased. Pre-treatment with both propranolol and glibenclamide abolished observed changes of antioxidant enzymes activity suggesting that ibogaine pro-antioxidative effectiveness is β -adrenergic receptors and KATP channels mediated. | sr |
dc.language.iso | en | sr |
dc.publisher | Basel: MDPI | sr |
dc.relation | Slovenian ARRS Programme, grant number P3-0171 | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Antioxidants | sr |
dc.subject | ibogaine | sr |
dc.subject | KATP channels | sr |
dc.subject | glibenclamide | sr |
dc.subject | β-adrenergic receptors | sr |
dc.subject | propranolol | sr |
dc.subject | antioxidative enzymes | sr |
dc.subject | superoxide dismutase | sr |
dc.subject | catalase | sr |
dc.subject | uterus | sr |
dc.subject | contractility | sr |
dc.title | Ibogaine-Mediated ROS/Antioxidant Elevation in Isolated Rat Uterus Is β-Adrenergic Receptors and KATP Channels Mediated | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dc.rights.holder | © 2021 by the authors. Licensee MDPI, Basel, Switzerland | sr |
dc.citation.issue | 11 | |
dc.citation.volume | 10 | |
dc.identifier.doi | 10.3390/antiox10111792 | |
dc.identifier.scopus | 2-s2.0-85118694432 | |
dc.identifier.wos | 000725783500001 | |
dc.citation.apa | Tatalović, N., Vidonja Uzelac, T., Oreščanin Dušić, Z., Nikolić-Kokić, A., Bresjanac, M., & Blagojević, D. (2021). Ibogaine-Mediated ROS/Antioxidant Elevation in Isolated Rat Uterus Is β-Adrenergic Receptors and KATP Channels Mediated. Antioxidants, 10(11), 1792. | |
dc.citation.vancouver | 1. Tatalović N, Vidonja Uzelac T, Oreščanin Dušić Z, Nikolić-Kokić A, Bresjanac M, Blagojević D. Ibogaine-Mediated ROS/Antioxidant Elevation in Isolated Rat Uterus Is β-Adrenergic Receptors and KATP Channels Mediated. Antioxidants. 2021;10(11):1792. | |
dc.citation.spage | 1792 | |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/9548/antioxidants-10-01792-v2.pdf | |
dc.citation.rank | aM21 |