Immunomodulation by heavy metals as a contributing factor to inflammatory diseases and autoimmune reactions: Cadmium as an example.
2021
Аутори:
Popov Aleksandrov, AleksandraMirkov, Ivana
Tucović, Dina
Kulaš, Jelena
Zeljković, Milica
Popović, Dušanka
Ninkov, Marina
Janković, Srđa
Kataranovski, Milena
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2021 European Federation of Immunological Societies
Метаподаци
Приказ свих података о документуАпстракт:
Cadmium (Cd) represents a unique hazard because of the long biological half-life in humans (20-30 years). This metal accumulates in organs causing a continuum of responses, with organ disease/failure as extreme outcome. Some of the cellular and molecular alterations in target tissues can be related to immune-modulating potential of Cd. This metal may cause adverse responses in which components of the immune system function as both mediators and effectors of Cd tissue toxicity, which, in combination with Cd-induced alterations in homeostatic reparative activities may contribute to tissue dysfunction. In this work, current knowledge concerning inflammatory/autoimmune disease manifestations found to be related with cadmium exposure are summarized. Along with epidemiological evidence, animal and in vitro data are presented, with focus on cellular and molecular immune mechanisms potentially relevant for the disease susceptibility, disease promotion, or facilitating development of pre-existing pathologies.
Кључне речи:
Cadmium; Disease promotion; Health effects; Inflammatory/autoimmune reactionsИзвор:
Immunology Letters, 2021, 240, 106-122Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
DOI: 10.1016/j.imlet.2021.10.003
ISSN: 0165-2478
PubMed: 34688722
WoS: 000727179200003
Scopus: 2-s2.0-85118330899
URI
https://linkinghub.elsevier.com/retrieve/pii/S0165247821001644http://radar.ibiss.bg.ac.rs/handle/123456789/4664