Molecular basis of obesity and cancer
2021
Аутори:
Kalezić, AnđelikaUdicki, Mirjana
Srdić Galić, Biljana
Korać, Aleksandra
Janković, Aleksandra
Korać, Bato
Тип документа:
Конференцијски прилог (Објављена верзија)
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© 2021 by the Serbian Nutrition Society
Метаподаци
Приказ свих података о документуАпстракт:
Global trends of increasing caloric consumption and decreasing physical activity have given rise to metabolic diseases in epidemic proportions. As a chronic state of altered metabolic and energy homeostasis,obesity is associated with various chronic diseases, including cancer. Alongside obesity, breast cancer incidence is also on the rise,even among premenopausal women. Acting through systemic and local influences, obesity could be viewed as a potential driving force for breast cancer development; however, this relationship seems rather complex. Accumulating evidence indicates that obesity decreasesthe incidence of breast cancer but increases rates of mortality,metastasis and therapeutic resistance in premenopausal women. We aim to provide an in-depth insight into the molecular mechanisms underlying the intriguing relationship between breast cancer and obesity by focusing on cross-examinationof metabolic alterations in breast cancer and cancer-associated adipose tissue. Metabolic reprogramming will be discussed through the potential influences obesityexerts on major pathways in glucose, lipid, and mitochondrial metabolism in breast cancer and cancer-associated adipose tissue. An overview of the wide-ranging implications of context-dependent metabolic reprogramming for personalized diagnostic and therapeutic approaches will be given.
Кључне речи:
obesity; cancer molecular baseУ:
- Book of Abstracts: 14th International Congress on Nutrition: A Place Where Science Meets Practice; 2021 Nov 8-10; Belgrade, Serbia. Belgrade: Serbian Nutrition Society; 2021. p. 55.