Ibogaine Has Sex-Specific Plasma Bioavailability, Histopathological and Redox/Antioxidant Effects in Rat Liver and Kidneys: A Study on Females
2021
Authors:
Tatalović, NikolaVidonja Uzelac, Teodora
Mijović, Milica
Koželj, Gordana
Nikolić-Kokić, Aleksandra
Oreščanin Dušić, Zorana
Bresjanac, Mara
Blagojević, Duško
Contributors
Dai, YiCacabelos, Ramón
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
Ibogaine induces rapid changes in cellular energetics followed by the elevation of antioxidant activities. As shown earlier in male rats, ibogaine treatment with both 1 and 20 mg/kg b.w. per os led to significant glycogenolytic activity in the liver. In this work, female rats treated with the same doses of ibogaine per os displayed lower liver glycogenolytic activity relative to males, dilatation of the central vein and branches of the portal vein, and increased concentration of thiols 6 h after treatment. These changes were followed by increased catalase activity and lipid peroxidation, and decreased xanthine oxidase activity after 24 h. In kidneys, mild histopathological changes were found in all treated animals, accompanied by a decrease of glutathione reductase (after 6 and 24 h at both doses) and an increase of catalase (6 h) and xanthine oxidase activity (6 and 24 h). Ibogaine did not affect antioxidant enzymes activity in erythrocytes. Bioavailability of ibogaine was two to three times higher in females than males, with similar kinetic profiles. Compared to previous results in males, ibogaine showed sex specific effect at the level of antioxidant cellular system. Effects of ibogaine in rats are sex- and tissue-specific, and also dose- and time-dependent.
Keywords:
noribogaine; erythrocytes; liver; kidney; glycogen; redox imbalance; catalase; xanthine oxidase; lipid peroxidation; thiolsSource:
Life, 2021, 12, 1, 16-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- ARRS, grant number P3-0171
DOI: 10.3390/life12010016
ISSN: 2075-1729
PubMed: 35054409