Rosmarinic acid–Modes of antimicrobial and antibiofilm activities of common plant polyphenol
2022
Тип документа:
Чланак у часопису (Објављена верзија)
,
© 2021 SAAB. Published by Elsevier B.V.
Метаподаци
Приказ свих података о документуАпстракт:
Emerging antimicrobial resistance and side effects associated with antibiotics overuse are driving the need for the novel antimicrobial therapeutics with the natural compounds considered as an appealing alternative. Rosmarinic acid is abundantly present in medicinal plants. This study aimed to elucidate its possible role as an inhibitor of planktonic and biofilm microorganism growth, along with its antifungal mechanisms. In this study, rosmarinic acid showed promising anticandidal (MIC 0.1–0.2 mg/mL) and antibacterial (MIC 0.002->0.8 mg/mL) activity. To some extent it was able to prevent cell attachment and eradicate established biofilms. Rosmarinic acid antifungal mechanisms included reduction of mitochondrial activity, alteration in membrane integrity, and slight inhibition of protease production but not binding to ergosterol. Its antibiofilm activity was moderately linked to the reduction in exopolysaccharide production. Considering its wide antimicrobial and antibiofilm spectrum rosmarinic acid could be further explored as an antimicrobial agent along with range of medicinal plants with rosmarinic acid as the dominant compound. Nevertheless, rosmarinic acid could serve as the basis for the development of antimicrobials employing novel mechanisms of activity.
Кључне речи:
Antibiofilm; Anticandidal; Mode of action; Polyphenolic compound; Rosmarinic acidИзвор:
South African Journal of Botany, 2022, 146, 521-527Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
Повезане информације:
- Друга верзија
https://radar.ibiss.bg.ac.rs/handle/123456789/4748
DOI: 10.1016/j.sajb.2021.11.050
ISSN: 0254-6299
WoS: 00078883640001
Scopus: 2-s2.0-85120878306
URI
https://linkinghub.elsevier.com/retrieve/pii/S025462992100497Xhttp://radar.ibiss.bg.ac.rs/handle/123456789/4745