dc.creator | Vratarić, Miloš | |
dc.creator | Šenk, Vladimir | |
dc.creator | Bursać, Biljana | |
dc.creator | Gligorovska, Ljupka | |
dc.creator | Ignjatović, Đurđica | |
dc.creator | Kovačević, Sanja | |
dc.creator | Veličković, Nataša | |
dc.creator | Đorđević, Ana | |
dc.date.accessioned | 2021-12-17T13:31:34Z | |
dc.date.accessioned | 2022-01-26T13:05:46Z | |
dc.date.available | 2022-11-12 | |
dc.date.available | 2022-11-12 | |
dc.date.issued | 2021 | |
dc.identifier.issn | 0951-6433 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/biof.1802 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/4773 | |
dc.description.abstract | Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that represents a link between diet-induced inflammation and insulin resistance. Our aim was to examine whether fructose diet affects inflammation and insulin signaling in the prefrontal cortex (PFC) of Mif knockout mice (MIF-KO), and their possible link to neural plasticity and behavior. We analyzed nuclear factor κB (NF-κB) and glucocorticoid signaling, expression of F4/80, IL-1β, TNF-α, TLR-4, MyD88, arginase 1 (Arg-1), mannose receptor (Mrc-1), and leukemia inhibitory factor (Lif) to assess inflammation in the PFC of C57/BL6J and MIF-KO mice consuming 20% fructose solution for 9 weeks. Insulin receptor (IR), IRS-1 serine phosphorylations (307 and 1101) and activity of PKCα, Akt, GSK-3β and AMPKα were used to analyze insulin signaling. Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) mRNA levels, together with synapthophysin and PSD-95 protein level and calcium calmodulin-dependent kinase 2 (CaMKII) activity, were used as plasticity markers. Behavior was examined in elevated plus maze, light dark box and novel object recognition test. The results showed concomitant increase of Tnf-α, Tlr-4, MyD88 and M2 microglia markers (Arg-1, Mrc-1, Lif) in the PFC of MIF-KO, paralleled with unchanged glucocorticoid and insulin signaling. Increase of BDNF and IGF-1 was paralleled with increased CaMKII activity, decreased PSD-95 protein level, anxiogenic behavior, and impaired memory in MIF-KO mice. Fructose feeding restored these parameters in the PFC to the control level and mitigated behavioral changes, suggesting that ameliorating effects of fructose on neuroinflammation and behavior depend on the presence of MIF. | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | |
dc.relation.isversionof | https://radar.ibiss.bg.ac.rs/handle/123456789/4687 | |
dc.rights | embargoedAccess | |
dc.source | BioFactors (Oxford, England) | |
dc.subject | Behavior | |
dc.subject | Fructose | |
dc.subject | Inflammation | |
dc.subject | Insulin resistance | |
dc.subject | Macrophage migration inhibitory factor | |
dc.subject | Neural plasticity | |
dc.subject | Prefrontal cortex | |
dc.title | Fructose diet ameliorates effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice. | |
dc.type | article | en |
dc.rights.license | ARR | |
dc.rights.holder | © 2021 International Union of Biochemistry and Molecular Biology. | |
dc.description.note | This is the peer reviewed version of the following article: Vratarić M, Šenk V, Bursać B, Gligorovska L, Ignjatović D, Kovačević S, Veličković N, Djordjevic A. Fructose diet ameliorates effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice. Biofactors. 2021, which has been published in final form at [http://dx.doi.org/10.1002/biof.1802]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. | |
dc.identifier.doi | 10.1002/biof.1802 | |
dc.identifier.pmid | 34767656 | |
dc.identifier.scopus | 2-s2.0-85118830262 | |
dc.identifier.wos | 000717722300001 | |
dc.citation.apa | Vratarić, M., Šenk, V., Bursać, B., Gligorovska, L., Ignjatović, D., Kovačević, S., et al. (2021). Fructose diet ameliorates effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice. BioFactors (Oxford, England). | |
dc.citation.vancouver | Vratarić M, Šenk V, Bursać B, Gligorovska L, Ignjatović D, Kovačević S, Veličković N, Djordjevic A. Fructose diet ameliorates effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice. Biofactors. 2021; | |
dc.type.version | acceptedVersion | |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/9897/bitstream_9897.pdf | |
dc.citation.rank | M21 | |