Late-Onset Calorie Restriction Worsens Cognitive Performances and Increases Frailty Level in Female Wistar Rats.
2021
Аутори:
Prvulović, MilicaMilanović, Desanka
Vujović, Predrag
Jović, Milena
Kanazir, Selma
Todorović, Smilja
Mladenović, Aleksandra
Тип документа:
Чланак у часопису (Рецензирана верзија)
,
The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America.
Метаподаци
Приказ свих података о документуАпстракт:
The current study aims to determine the potential benefits of calorie restriction (CR), one of the most promising paradigms for life span and healthspan extension, on cognitive performances in female Wistar rats during aging. As a measure of a healthspan, we evaluated the effects of different onset and duration of CR on frailty level. Female Wistar rats were exposed to either ad libitum (AL) or CR (60% of AL daily intake) food intake during aging. Two different CR protocols were used, life-long CR with an early-onset that started at the adult stage (6 months) and 3-month-long CR, started at the middle (15 months) and late-middle (21 months) age, thus defined as a late-onset CR. The effects of CR were evaluated using open-field, Y-maze, and novel object recognition tests. We broadened 2 tools for frailty assessment currently in use for experimental animals, and in alignment with our previous study, we created a physical-cognitive frailty tool that combines both physical and cognitive performances. Our results clearly showed that CR effects are highly dependent on CR duration and onset. While a life-long restriction with an early-onset has been proven as protective and beneficial, short-term restriction introduced at late age significantly worsens an animal's behavior and frailty. These results complement our previous study conducted in males and contribute to the understanding of sex differences in a response to CR during aging.
Напомена:
This is a pre-copyedited, author-produced version of an article accepted for publication in The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences following peer review. The version of record Prvulovic MR, Milanovic DJ, Vujovic PZ, Jovic MS, Kanazir SD, Todorovic ST, Mladenovic AN. Late-Onset Calorie Restriction Worsens Cognitive Performances and Increases Frailty Level in Female Wistar Rats. Le Couteur DG, editor. Journals Gerontol Ser A Biol Sci Med Sci. 2021;glab353. is available online at: https://doi.org/10.1093/gerona/glab353.
Кључне речи:
Aging; Healthspan; Memory; Nutrition; SexИзвор:
The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2021, 77, 5, glab353-955Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
Повезане информације:
- Друга верзија
https://radar.ibiss.bg.ac.rs/handle/123456789/5436
DOI: 10.1093/gerona/glab353
ISSN: 1079-5006
PubMed: 34957511
WoS: 000790110100001
Scopus: 2-s2.0-85130434140
URI
https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glab353/6433769http://radar.ibiss.bg.ac.rs/handle/123456789/4774