Frailty index of aging female rats changes under diferent dietary protocols
2021
Тип документа:
Конференцијски прилог (Објављена верзија)
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© 2021 Published by Elsevier Inc.
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The continuous increase of a lifespan imposes need to prolong the healthspan - period of life spent free of age-related disabilities. Some interventions such as dietary restriction (DR) can retard aging process, improve quality of life and increase healthspan. However, recent studies have re-evaluated generality of DR’s beneficial effect, as different outcomes of DR have been reported in dependence of onset and duration of DR. In order to test the impact of various dietary restricted regimens in female rats during aging, we used frailty assessment as one of the best indicators of healthspan. Female Wistar rats of various age (young adult, middle-age and aged) were exposed to DR (60 % of AL daily intake) feeding regimens. We determined and compared frailty index (FI) during aging in ad libitum fed (AL) and in rats exposed to DR. Frailty index was constructed using 22 parameters. FI was increased in both 18- and 24-month-old AL animals in comparison to young control counterparts. Life-long type of restricted diet decreased FI in 18- month old group while shorter duration of DR regimens failed to lower frailty index in 18- and 24- month-old animals. Our results indicated that life-long DR can alter animal’s frailty during aging, while shorter duration and later onset DR have no effect on FI in female rats
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- Free Radical Research Europe (SFRR-E): Annual Meeting Abstracts: “Redox biology in the 21st century: a new scientific discipline”; 2021 Jun 15-18; Belgrade, Serbia. Elsevier; 2021. p. S96. (Free Radical Biology and Medicine; Vol. 177; Suppl. 1).