Some hematological values and transaminase activites in the plasma of rats treated with cadmium and coenzyme Q10

Abstract

In our experiments the red blood cells (RBC) count, hematocrite value (Ht), hemoglobin (Hb) and glucose concentrations in the blood, as well as, the plasma cholesterol concentration and activities of aspartat aminotransaminase (AST) and alanin aminotransaminase (ALT) of male Wistar albino rats were determined. Besides the controls (C), experimental animals were treated with: cadmium (Cd, 17 mg/day/kg body mass in drinking water + 100 μL olive oil, i.m., every fifth day), coenzyme Q10 (CoQ10,16 mg/kg, dissolved in olive oil, i.m., every fifth day), concomitantly treated with Cd and CoQ10 (Cd+CoQ10, 17 mg Cd/day kg body mass in drinking water + 16 mg/kg CoQ10, dissolved in olive oil, i.m., every fifth day) and olive oil (o. oil, 100 μL, i.m., every fifth day) during 30 days. The obtained results show that Cd induces a significant decrease of RBC count, Hb and cholesterol concentrations and Ht value. At the same time Cd induces a statistically significant increase of plasma transaminase activities. In animals treated with CoQ10 statistically significant decrease of glucose concentration was observed. In rats concomitantly exposed to Cd+CoQ10 we found a significant decrease of RBC count and glucose concentration, while in the same group of animals plasma AST and ALT activities were significantly increased. In the same group of animals Hb concentration was normalized in respect to the rats treated only with Cd. .