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The effect of selenium on antioxidant defense system in the blood of rats chronically treated with cadmium
dc.creator | Pavlović, Slađan | |
dc.creator | Ognjanović, Branka I. | |
dc.creator | Žikić, Radoslav V. | |
dc.creator | Štajn, Andraš Š. | |
dc.creator | Saičić, Zorica | |
dc.creator | Petrović, Vojislav M. | |
dc.date.accessioned | 2015-08-28T10:26:51Z | |
dc.date.available | 2015-08-28T10:26:51Z | |
dc.date.issued | 2001 | |
dc.date.issued | 2001 | sr |
dc.identifier.issn | 1450-9636 | sr |
dc.identifier.other | Rad_konverzija_527 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/486 | |
dc.description.abstract | The effect of selenium (Se, 7 µg/kg/day, during 30 days) on the antioxidant defense system (AOS): copper zinc containing superoxide dismutase (CuZn SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities in red blood cells (RBC) and glutathione-S-transferase (GST) activity in the plasma, as well as ascorbic acid (AsA) and vitamin E (Vit E) concentrations in the plasma of rats chronically treated with cadmium (Cd, 15 mg/kg/day, during 30 days) was analyzed. All results of experimental groups were compared with control animals. Cd led to increased the activities of CuZn SOD, CAT and GSH-Px, as well as GST activity and Vit E concentration. Se induced a significant increase in GSH-Px and GST activities, as well as concentrations of AsA and Vit E. In animals exposed both to Cd and Se a significant increase of GSH-Px activity was observed. The accumulation of Cd was significantly increased in the plasma of Cd+Se treated and in RBC of Cd treated animals, while it was markedly lower in RBC of Cd+Se treated rats. The obtained results show, that Cd exhibit toxic effects on the antioxidant defense system in the blood of rats and that Se demonstrates protective role against Cd toxicity. | en |
dc.description.sponsorship | Projekat ministarstva br. 03E18 i 03E23 | sr |
dc.language.iso | eng | sr |
dc.rights | openAccess | sr |
dc.source | Kragujevac Journal of Science | sr |
dc.title | The effect of selenium on antioxidant defense system in the blood of rats chronically treated with cadmium | en |
dc.type | article | sr |
dc.rights.license | ARR | |
dcterms.abstract | Павловић, Слађан З.; Саичић, Зорица; Штајн, Aндраш Ш.; Петровић, Војислав М.; Огњановић, Бранка И.; Жикић, Радослав В.; | |
dc.citation.issue | 23 | sr |
dc.citation.volume | null | sr |
dc.citation.spage | 105 | sr |
dc.citation.epage | 114 | sr |
dc.type.version | publishedVersion | sr |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_486 |
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