Rosmarinic acid – plant polyphenol with antimicrobial and antibiofilm potential
2021
Аутори:
Ivanov, MarijaKostić, Marina
Stojković, Dejan
Soković, Marina
Остала ауторства
Barros, LillianCastañeda, Bruno Melgar
Shiraishi, Carlos Seiti Hurtado
Тип документа:
Конференцијски прилог (Објављена верзија)
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© 2021 by the Instituto Politécnico de Bragança
Метаподаци
Приказ свих података о документуАпстракт:
Increasing antimicrobial resistance accompanied by range of side effects linked to antibiotics overuse are
urging the demand for the novel antimicrobials with the ones obtained from natural sources considered as
an appealing alternative. Rosmarinic acid is naturally occurring plant polyphenol. This study aimed to
enlighten its potential role as inhibitor of planktonic and biofilm microorganism growth, along with its
antifungal mechanisms. In this study, rosmarinic acid has shown promising anticandidal (MIC 0.1-0.2
mg/mL) (Table 1) and antibacterial (MIC 0.05->0.8 mg/mL) activity. To some extent rosmarinic acid was
able to reduce attachment of fungal cells to abiotic surface, first stage in biofilm formation process, and
eradicate preformed biofilms. Rosmarinic acid antifungal mode of action involves interference with
membrane integrity, but not binding to membrane lipid, ergosterol, or reduction in protease production;
while its antibiofilm activity is moderately attributed to decrease in exopolysaccharide production.
Considering its wide antimicrobial and antibiofilm capacity rosmarinic acid could be further examined as
antimicrobial agent along with range of medicinal plants with rosmarinic acid as the dominant compound.
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
У:
- Barros L, Castañeda BM, Shiraishi CSH, editors. Book of Abstracts: 1st Natural products application: Health, Cosmetic and Food: book of abstracts; 2021 Feb 4-5; Online. Bragança: Instituto Politécnico de Bragança; 2021. p. 148.