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Plant extracts as potential bioactive food additives
dc.contributor | Cilla, Antonio | |
dc.creator | Nunes Silva, Beatriz | |
dc.creator | Cadavez, Vasco | |
dc.creator | Caleja, Cristina | |
dc.creator | Pereira, Eliana | |
dc.creator | Calhelha, Ricardo C. | |
dc.creator | Pinela, José | |
dc.creator | Kostić, Marina | |
dc.creator | Soković, Marina | |
dc.creator | Teixeira, José A. | |
dc.creator | Barros, Lillian | |
dc.creator | Gonzales-Barron, Ursula | |
dc.date.accessioned | 2022-04-04T12:54:35Z | |
dc.date.available | 2022-04-04T12:54:35Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/4931 | |
dc.description.abstract | Plant extracts have potential as food additives. In this sense, this work aimed to study the bioactivities of plant extracts and their ability as health-promoting additives. Lavender, lemon balm, basil, tarragon, sage, and spearmint dry aerial parts were mechanically ground. Three extraction methods were tested: infusion and decoction, using distilled water as solvent and a sample/solvent ratio of 1:100; and hydroethanolic extraction, using ethanol 80% (v/v) as solvent and a sample/solvent ratio of 1:60. The extracts obtained were evaluated for their antimicrobial and antifungal activities, by a microdilution method. The antioxidant activity was evaluated through the lipid peroxidation inhibition assay (TBARS) and the oxidative haemolysis inhibition assay (OxHLIA). Cytotoxic activity was evaluated in tumour and non-tumour cell lines using the sulforhodamine B method, and anti-inflammatory activity in lipopolysaccharide-activated RAW 264.7 macrophages by the ability to inhibit NO production. The results showed that all extracts exhibited antimicrobial activity against six pathogens tested (MIC ≤ 2 mg/mL) and antifungal capacity against, at least, five fungi (MFC ≤ 1 mg/mL). In the TBARS evaluation, lemon balm infusion (125±2 μg/mL) and hydroethanolic extracts of spearmint (132±5 μg/mL) and lavender (177±4 μg/mL) presented the highest activities. In the OxHLIA assay, sage decoction (8.9±0.4 μg/mL) and hydroethanolic extracts of spearmint (12.5±0.2 μg/mL) and lemon balm (13.5±0.4 μg/mL) showed the best capacities to inhibit oxidative haemolysis. Regarding the anti-inflammatory activity, only the extracts of spearmint and basil, and the decoction and hydroethanolic extracts of tarragon, showed promising results (GI50<89 μg/mL). As for the cytotoxicity assay, most extracts (except those of tarragon and the infusion and decoction of basil) revealed anti-proliferative capacity in the AGS, CaCo, and HeLa tumour lines (GI50<400 μg/mL). These outcomes provide insight on the bioactivity of numerous herbal extracts, emphasising their value as food additives to prevent spoilage and deliver beneficial health effects. | sr |
dc.language.iso | en | sr |
dc.publisher | Basel: MDPI | sr |
dc.relation | FCT 36 | sr |
dc.relation | Healthy-PETFOOD | sr |
dc.relation | Project Mobilizador Norte-01-0247-FEDER-024479 | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Proceesings: The 2nd International Electronic Conference on Foods - "Future Foods and Food Technologies for a Sustainable World"; 2021 Oct 15-30; Online | sr |
dc.subject | antioxidants | sr |
dc.subject | antimicrobials | sr |
dc.subject | preservatives | sr |
dc.subject | antiproliferative effect | sr |
dc.subject | anti-inflammatory effect | sr |
dc.title | Plant extracts as potential bioactive food additives | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dc.rights.holder | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | sr |
dc.description.other | Cilla A, editor. Proceedings: The 2nd International Electronic Conference on Foods - "Future Foods and Food Technologies for a Sustainable World"; 2021 Oct 15-30; Online. Basel: MDPI, 2021. p. 11010. (Biology and Life Sciences Forum; Vol. 6; No. 1). | sr |
dc.identifier.doi | 10.3390/Foods2021-11010 | |
dc.citation.spage | 11010 | |
dc.type.version | submittedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/11382/blsf-06-00116.pdf | |
dc.citation.rank | M33 |