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C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators.
dc.creator | Ntungwe, Epole N. | |
dc.creator | Jovanović Stojanov, Sofija | |
dc.creator | Duarte, Noélia M. | |
dc.creator | Candeias, Nuno R. | |
dc.creator | Díaz-Lanza, Ana M. | |
dc.creator | Vágvölgyi, Máté | |
dc.creator | Hunyadi, Attila | |
dc.creator | Pešić, Milica | |
dc.creator | Rijo, Patrícia | |
dc.date.accessioned | 2022-04-27T12:49:00Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1948-5875 | |
dc.identifier.uri | https://pubs.acs.org/doi/10.1021/acsmedchemlett.1c00711 | |
dc.identifier.uri | http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9014510 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/4945 | |
dc.description.abstract | In this study, a bioguided fractionation of Plectranthus mutabilis extract was performed by chromatographic methods. It yielded one new nor-abietane diterpene, mutabilol (1), and three known abietanes, coleon-U-quinone (2), 8α,9α-epoxycoleon-U-quinone (3), and coleon U (4). The abietane diterpenoid 5 was also tentatively identified using HPLC-MS/MS. Moreover, the extract profile and quantification of each isolated compound were determined by HPLC-DAD. Compound 4 was the major compound in the extract. Compounds 2-4 were found to be selective toward cancer cell lines and were able to inhibit P-glycoprotein (P-gp) activity in NCI-H460/R cells at longer exposure of 72 h and consequently revert doxorubicin (DOX) resistance in subsequent combined treatment. None of the compounds influenced the P-gp expression in NCI-H460/R cells, while the extract significantly increased it. | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | |
dc.rights | restrictedAccess | |
dc.source | ACS Medicinal Chemistry Letters | |
dc.subject | Abietane diterpenoids | |
dc.subject | Anticancer effect | |
dc.subject | Multidrug resistance | |
dc.subject | P-glycoprotein | |
dc.subject | Plectranthus mutabilis | |
dc.title | C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators. | |
dc.type | article | en |
dc.rights.license | ARR | |
dc.rights.holder | © 2022 American Chemical Society | |
dc.citation.issue | 4 | |
dc.citation.volume | 13 | |
dc.identifier.doi | 10.1021/acsmedchemlett.1c00711 | |
dc.identifier.pmid | 35450348 | |
dc.identifier.scopus | 2-s2.0-85126589451 | |
dc.identifier.wos | 000791541600029 | |
dc.citation.apa | Ntungwe, E. N., Jovanović Stojanov, S., Duarte, N. M., Candeias, N. R., Díaz-Lanza, A. M., Vágvölgyi, M., et al. (2022). C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators. ACS Medicinal Chemistry Letters, 13(4), 674–680. | |
dc.citation.vancouver | Ntungwe EN, Jovanović Stojanov S, Duarte NM, Candeias NR, Díaz-Lanza AM, Vágvölgyi M, Hunyadi A, Pešić M, Rijo P. C20-nor-Abietane and Three Abietane Diterpenoids from Plectranthus mutabilis Leaves as P-Glycoprotein Modulators. ACS Med Chem Lett. 2022;13(4):674–80. | |
dc.citation.spage | 674 | |
dc.citation.epage | 680 | |
dc.type.version | publishedVersion | |
dc.citation.rank | M22 |