Orally administered fluorescent nanosized polystyrene particles affect cell viability, hormonal and inflammatory profile, and behavior in treated mice.
2022
Autori:
Nikolić, SandraGazdić-Janković, Marina
Rosić, Gvozden
Miletić-Kovačević, Marina
Jovičić, Nemanja
Nestorović, Nataša
Stojković, Petra
Filipović, Nenad
Milošević-Đorđević, Olivera
Selaković, Dragica
Živanović, Marko
Seklić, Dragana
Milivojević, Nevena
Marković, Aleksandra
Seist, Richard
Vasilijić, Sasa
Stanković, Konstantina M.
Stojković, Miodrag
Ljujić, Biljana
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
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© 2022 Elsevier Ltd.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Commercially manufactured or generated through environmental degradation, microplastics (MPs) and nanoplastics (NPs) considerably contribute to environmental pollution. There is a knowledge gap in how exposure to MPs/NPs changes cellular function and affects animal and human health. Here, we demonstrate that after oral uptake, fluorescent polystyrene (PS) nanoparticles pass through the mouse digestive system, accumulate and aggregate in different organs, and induce functional changes in cells and organs. Using cochlear explant as a novel in vitro system, we confirmed the consequences of PS-MP/NP interaction with inner ear cells by detecting aggregates and hetero-aggregates of PS particles in hair cells. The testes of treated males accumulated MPs/NPs in the interstitial compartment surrounding the seminiferous tubules, which was associated with a statistically significant decrease in testosterone levels. Male mice showed increased secretion of interleukins (IL-12p35 and IL-23) by splenocytes while cyto- and genotoxicity tests indicated impaired cell viability and increased DNA damage in spleen tissue. Males also showed a broad range of anxiogenic responses to PS nanoparticles while hippocampal samples from treated females showed an increased expression of Bax and Nlrp3 genes, indicating a pro-apoptotic/proinflammatory effect of PS treatment. Taken together, induced PS effects are also gender-dependent, and therefore, strongly motivate future research to mitigate the deleterious effects of nanosized plastic particles.
Ključne reči:
Accumulation; Behavior; Mice; Microplastics; Nanoplastics; PolystyreneIzvor:
Environmental Pollution, 2022, 305, 119206-Finansiranje / projekti:
- Razvoj infrastrukture za prioritetna polja nauke (RS-MESTD-Basic Research (BR or ON)-175103)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200107 (Univerzitet u Kragujevcu, Fakultet inženjerskih nauka) (RS-MESTD-inst-2020-200107)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200378 (Institut za informacione tehnologije, Kragujevac) (RS-MESTD-inst-2020-200378)
DOI: 10.1016/j.envpol.2022.119206
ISSN: 0269-7491
PubMed: 35405220