Morfofunkcionalne osobine hipofiznih adrenokortikotropa u životinjskom modelu toplotnog stresa
Morphofunctional characteristics of pituitary adrenocorticotropes in an animal model of heat stress
dc.creator | Perčinić-Popovska, Florina | |
dc.creator | Ajdžanović, Vladimir | |
dc.creator | Dinevska-Kofkarovska, Suzana | |
dc.creator | Jordanova, Maja | |
dc.creator | Trifunović, Svetlana | |
dc.creator | Šošić-Jurjević, Branka | |
dc.creator | Milošević, Verica | |
dc.date.accessioned | 2015-08-28T10:26:51Z | |
dc.date.available | 2015-08-28T10:26:51Z | |
dc.date.issued | 2011 | sr |
dc.date.issued | 2011 | |
dc.identifier.issn | 1452-8258 | sr |
dc.identifier.other | Rad_konverzija_536 | sr |
dc.identifier.uri | https://radar.ibiss.bg.ac.rs/handle/123456789/496 | |
dc.description.abstract | As a result of the global warming, the average ambient temperature during summertime has increased in regions with moderate continental climate. The effects of 24 h exposure to heat stress (35±1 °C) on the morphology and function of pituitary adrenocorti cotropes were examined in adult male Wistar rats. Significant changes in the morphofunctional features of adrenocorti cotropes were found after the heat stress, with no differences noted in the cell shape or localization, com pared to controls. The adrenocorti cotropes cell volume, as well as the volume density, were significantly decreased (p<0.05) by 12.3% and 26.7%, respectively, in comparison with controls. The concentration of plasma adrenocorti cotropic hormone and serum corticosterone in the heat stressed group were significantly decreased (p<0.05) by 21.9% and 27.2%, respectively, compared to controls. These findings suggest that 24 h exposure of adult male rats to heat stress has an inhibitory effect on the morphofunctional characteristics of adrenocorticotropes. | en |
dc.description.abstract | Usled globalnog otopljavanja u regionima sa umereno kontinentalnom klimom dolazi do povećanja srednje vrednosti temperature vazduha to kom letnjih meseci. U ovoj studiji ispitivani su efekti 24-časovnog izlaganja to plotnom stresu (35±1 °C) na morfologiju i funkciju hipofiznih adrenokortikotropa kod odraslih pacova Wistar soja. Dobijeni rezultati ukazuju na značajne promene u morfofunkcionalnim osobinama adrenokortiko tropa nakon izlaganja toplotnom stresu, bez uočenih razlika u obliku i lokalizaciji ćelija u poređenju sa kontrolama. Volumen adrenokortikotropa kao i njihova volumenska gustina bili su značajno smanjeni (p<0,05) za 12,3% odnosno 26,7%, u poređenju sa kontrolom. Koncentracije adrenokortikotropnog hormona u plazmi i kortikosterona u serumu u eksperimentalnoj grupi bile su značajno smanjene za 21,9% odnosno 27,2%, u poređenju sa kontrolnim vrednostima. Navedeni rezultati pokazuju da 24-časovno izlaganje odraslih mužjaka pacova toplotnom stresu ima inhibirajući efekat na morfofunkcionalne osobine hipofiznih adrenokortikotropa. | sr |
dc.description.sponsorship | null | sr |
dc.language.iso | eng | sr |
dc.publisher | Belgrade: Society of Medical Biochemists of Serbia | |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Journal of Medical Biochemistry | sr |
dc.subject | heat stress | ENG |
dc.subject | toplotni stres | SRP |
dc.subject | ACTH | SRP |
dc.subject | ACTH | ENG |
dc.subject | male rats | ENG |
dc.subject | mužjaci pacova | SRP |
dc.title | Morfofunkcionalne osobine hipofiznih adrenokortikotropa u životinjskom modelu toplotnog stresa | sr |
dc.title | Morphofunctional characteristics of pituitary adrenocorticotropes in an animal model of heat stress | en |
dc.type | article | sr |
dc.rights.license | BY | |
dcterms.abstract | Перчинић-Поповска, Флорина; Диневска-Кофкаровска, Сузана; Јорданова, Маја; Трифуновић, Светлана; Милошевић, Верица; Aјджановић, Владимир; Шошић-Јурјевић, Бранка; Морфофункционалне особине хипофизних адренокортикотропа у животињском моделу топлотног стреса; Морфофункционалне особине хипофизних адренокортикотропа у животињском моделу топлотног стреса; | |
dc.rights.holder | © 2011 by the Society of Medical Biochemists of Serbia | |
dc.citation.issue | 4 | sr |
dc.citation.volume | 30 | sr |
dc.identifier.doi | 10.2478/v10011-011-0030-6 | |
dc.identifier.scopus | 2-s2.0-80051498216 | |
dc.identifier.wos | 000293508800003 | |
dc.citation.spage | 287 | sr |
dc.citation.epage | 292 | sr |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs//bitstream/id/3037/Rad_konverzija_536.pdf | |
dc.citation.rank | M23 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_ibiss_496 |