Catmint (Nepeta nuda L.) Phylogenetics and Metabolic Responses in Variable Growth Conditions.
2022
Аутори:
Petrova, DetelinaGašić, Uroš
Yocheva, Lyubomira
Hinkov, Anton
Yordanova, Zhenya
Chaneva, Ganka
Mantovska, Desislava
Paunov, Momchil
Ivanova, Lyubomira
Rogova, Mariya
Shishkova, Kalina
Todorov, Daniel
Tosheva, Anita
Kapchina-Toteva, Veneta
Vassileva, Valya
Atanassov, Atanas
Mišić, Danijela
Bonchev, Georgi
Zhiponova, Miroslava
Тип документа:
Чланак у часопису (Објављена верзија)
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© 2022 Petrova, Gašić, Yocheva, Hinkov, Yordanova, Chaneva, Mantovska, Paunov, Ivanova, Rogova, Shishkova, Todorov, Tosheva, Kapchina-Toteva, Vassileva, Atanassov, Mišić, Bonchev and Zhiponova.
Метаподаци
Приказ свих података о документуАпстракт:
Nepeta nuda (catmint; Lamiaceae) is a perennial medicinal plant with a wide geographic distribution in Europe and Asia. This study first characterized the taxonomic position of N. nuda using DNA barcoding technology. Since medicinal plants are rich in secondary metabolites contributing to their adaptive immune response, we explored the N. nuda metabolic adjustment operating under variable environments. Through comparative analysis of wild-grown and in vitro cultivated plants, we assessed the change in phenolic and iridoid compounds, and the associated immune activities. The wild-grown plants from different Bulgarian locations contained variable amounts of phenolic compounds manifested by a general increase in flowers, as compared to leaves, while a strong reduction was observed in the in vitro plants. A similar trend was noted for the antioxidant and anti-herpesvirus activity of the extracts. The antimicrobial potential, however, was very similar, regardless the growth conditions. Analysis of the N. nuda extracts led to identification of 63 compounds including phenolic acids and derivatives, flavonoids, and iridoids. Quantification of the content of 21 target compounds indicated their general reduction in the extracts from in vitro plants, and only the ferulic acid (FA) was specifically increased. Cultivation of in vitro plants under different light quality and intensity indicated that these variable light conditions altered the content of bioactive compounds, such as aesculin, FA, rosmarinic acid, cirsimaritin, naringenin, rutin, isoquercetin, epideoxyloganic acid, chlorogenic acid. Thus, this study generated novel information on the regulation of N. nuda productivity using light and other cultivation conditions, which could be exploited for biotechnological purposes.
Кључне речи:
DNA barcoding; Nepeta nuda; Antibacterial; Antioxidant; Antiviral; Iridoids; Light; PhenolicsИзвор:
Frontiers in Plant Science, 2022, 13, 866777-Финансирање / пројекти:
- Grant BG05M2OP001-1.002-0012-C01 “Sustainable utilization of bio-resources and waste of medicinal and aromatic plants for innovative bioactive products”
- National Science Fund of Bulgaria (KP-06-N56/9/12.11.2021)
- Ministry of Education and Science of Bulgaria, Project BULCode (No. Д01-271/02.10.2020)
- Operational Program Science and Education for Smart Growth 2018–2023
DOI: 10.3389/fpls.2022.866777
ISSN: 1664-462X
PubMed: 35651766
WoS: 000804598800001
[ Google Scholar ]URI
https://www.frontiersin.org/articles/10.3389/fpls.2022.866777/fullhttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9150856
http://radar.ibiss.bg.ac.rs/handle/123456789/5003