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Antimicrobial and Cytotoxic Activities of Selected Hieracium L. s. str. (Asteraceae) Extracts and Isolated Sesquiterpene Lactones.
dc.creator | Milutinović, Violeta M. | |
dc.creator | Matić, Ivana Z. | |
dc.creator | Stanojković, Tatjana P. | |
dc.creator | Soković, Marina | |
dc.creator | Ćirić, Ana | |
dc.creator | Ušjak, Ljuboš J. | |
dc.creator | Niketić, Marjan S. | |
dc.creator | Petrović, Silvana D. | |
dc.date.accessioned | 2022-06-23T10:46:31Z | |
dc.date.available | 2900-01-01 | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1612-1872 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202200326 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/5005 | |
dc.description.abstract | Antimicrobial and cytotoxic activities were tested for dried MeOH extracts of Hieracium calophyllum (CAL), H. coloriscapum (COL), H. pseudoschenkii (PSE), H. valdepilosum (VAL) and H. glabratum (GLA) herbs (flowering aerial parts), their 2 sesquiterpene lactones (SLs) 8-epiixerisamine A and crepiside E, and dried CH2 Cl2 extract of H. scheppigianum (SCH) herb. In microdilution test, extracts showed activity on all tested microorganisms (8 bacteria, 10 fungi). The best effect was exhibited by SCH and CAL on Salmonella Typhimurium (MIC=1.7-2.5 mg/mL MBC=3.4-5.0 mg/mL), and SCH and VAL on Candida albicans (MIC=2.5 mg/mL MFC=5.0 mg/mL). SLs showed notable effect on all tested fungi Aspergillus ochraceus, Penicillium funiculosum, C. albicans and C. krusei (MIC=0.15-0.4 mg/mL MFC=0.3-0.8 mg/mL). In MTT test, extracts inhibited growth of all tested cancer cells (HeLa, LS174 and A549), with the best effect on HeLa (IC50 =148.1 μg/mL for SCH, and 152.3-303.2 μg/mL for MeOH extracts); both SLs were active against HeLa cells (IC50 =46.2 μg/mL for crepiside E and 103.8 μg/mL for 8-epiixerisamine A). Extracts and SLs showed good safety profile on normal MRC-5 cells. | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200043/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200161/RS// | |
dc.rights | restrictedAccess | |
dc.source | Chemistry & Biodiversity | |
dc.subject | Hieracium species | |
dc.subject | Antimicrobial activity | |
dc.subject | Cytotoxicity | |
dc.subject | Flowering aerial parts extracts | |
dc.subject | Terpenoids | |
dc.title | Antimicrobial and Cytotoxic Activities of Selected Hieracium L. s. str. (Asteraceae) Extracts and Isolated Sesquiterpene Lactones. | |
dc.type | article | en |
dc.rights.license | ARR | |
dc.rights.holder | © 2022 Wiley‐VHCA AG, Zurich, Switzerland | |
dc.citation.issue | 7 | |
dc.citation.volume | 19 | |
dc.identifier.doi | 10.1002/cbdv.202200326 | |
dc.identifier.pmid | 35621325 | |
dc.identifier.scopus | 2-s2.0-85131363392 | |
dc.identifier.wos | 000807699400001 | |
dc.citation.apa | Milutinović, V. M., Matić, I. Z., Stanojković, T. P., Soković, M. D., Ćirić, A. D., Ušjak, L. J., et al. (2022). Antimicrobial and Cytotoxic Activities of Selected Hieracium L. s. str. (Asteraceae) Extracts and Isolated Sesquiterpene Lactones. Chemistry & Biodiversity, 19(7), e202200326. | |
dc.citation.vancouver | Milutinović VM, Matić IZ, Stanojković TP, Soković MD, Ćirić AD, Ušjak LJ, Niketić MS, Petrović SD. Antimicrobial and Cytotoxic Activities of Selected Hieracium L. s. str. (Asteraceae) Extracts and Isolated Sesquiterpene Lactones. Chem Biodivers. 2022;19(7):e202200326. | |
dc.citation.spage | e202200326 | |
dc.type.version | publishedVersion | |
dc.citation.rank | M22 |