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Chokeberry (Aronia melanocarpa) fruit extract abrogates melanoma progression through boosting up IFN-γ-producing cells
dc.creator | Mićanović, Dragica | |
dc.creator | Stojanović, Ivana D. | |
dc.creator | Koprivica, Ivan | |
dc.creator | Pejnović, Nada | |
dc.creator | Šavikin, Katarina | |
dc.creator | Ćujić-Nikolić, Nada | |
dc.creator | Saksida, Tamara | |
dc.date.accessioned | 2022-08-31T10:53:39Z | |
dc.date.available | 2022-08-31T10:53:39Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 1756-4646 | |
dc.identifier.uri | http://radar.ibiss.bg.ac.rs/handle/123456789/5021 | |
dc.description.abstract | Chokeberry has exhibited cardioprotective, anti-bacterial, immunomodulating and anti-cancer properties. Chokeberry extract (CE) was tested in the model of melanoma induced by B16 cells inoculation in C57BL/6 mice. CE treatment that began 7 days before inoculation and continued through the observation period, delayed melanoma appearance and increased infiltration of immune cells in the tumor microenvironment (TME). Levels of TNF, perforin, granzyme B and IL-1β did not differ between the CE-treated and control animals, but the TME of CE-treated mice contained more IFN-γ-producing cells and a lesser frequency of CCR5-expressing MDSC. In vitro, CE displayed no direct cytotoxicity to B16 cells. However, splenocytes isolated from CE-treated animals exerted strong cytotoxic effect on B16 cells in vitro. Neutralization of IFN-γ diminished the observed B16 death, suggesting that this effect was mediated mainly by splenocyte-derived IFN-γ. In conclusion, pre-treatment with CE stimulated the anti-tumor immune response by enhancing IFN-γ-producing cells to act against melanoma. | sr |
dc.language.iso | en | sr |
dc.publisher | Amsterdam : Elsevier | sr |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS// | sr |
dc.rights | openAccess | sr |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Journal of Functional Foods | sr |
dc.subject | Aronia melanocarpa | sr |
dc.subject | Melanoma | sr |
dc.subject | B16 cells | sr |
dc.subject | Anti-tumor immune response | sr |
dc.subject | NK cells | sr |
dc.subject | CD8+ T lymphocyte | sr |
dc.title | Chokeberry (Aronia melanocarpa) fruit extract abrogates melanoma progression through boosting up IFN-γ-producing cells | sr |
dc.type | article | sr |
dc.rights.license | BY | sr |
dc.rights.holder | © 2022 The Authors. Published by Elsevier Ltd. | sr |
dc.citation.volume | 95 | |
dc.identifier.doi | 10.1016/j.jff.2022.105185 | |
dc.identifier.scopus | 2-s2.0-85134797850 | |
dc.identifier.wos | 000831669700010 | |
dc.citation.apa | Gajić, D., Stojanović, I., Koprivica, I., Pejnović, N., Šavikin, K., Ćujić-Nikolić, N., et al. (2022). Chokeberry (Aronia melanocarpa) fruit extract abrogates melanoma progression through boosting up IFN-γ-producing cells. Journal of Functional Foods, 95, 105185. | |
dc.citation.vancouver | Gajić D, Stojanović I, Koprivica I, Pejnović N, Šavikin K, Ćujić-Nikolić N, Saksida T. Chokeberry (Aronia melanocarpa) fruit extract abrogates melanoma progression through boosting up IFN-γ-producing cells. J Funct Foods. 2022;95:105185. | |
dc.citation.spage | 105185 | |
dc.type.version | publishedVersion | sr |
dc.identifier.fulltext | https://radar.ibiss.bg.ac.rs/bitstream/id/10779/bitstream_10779.pdf | |
dc.citation.rank | M21 |