Comparison of bromazepam and ibuprofen influence on tooth pulp-evoked potentials in humans
2022
Autori:
Vukovic, BranislavaLazic, Zoran
Avramov, Stevan
Pavlović, Maja
Čabrilo-Lazić, Milana
Malešević, Adam
Trifunović, Jovanka
Nikolić, Živorad
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
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© 2022 by the Serbian Medical Society
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Introduction/Objective. Somatosensory evoked potentials are a neurophysiological tool for testing the effects of drugs in humans and animals. The aim of this study was to estimate the way that bromazepam and ibuprofen had on tooth pulp-evoked potentials (TPEPs) after non-painful stimuli, as well as to detect possible differences in this activity. Methods. Sixty young healthy subjects were included in the study. They were arranged into three groups: ibuprofen, bromazepam, and placebo. To record TPEPs response, dental pulp were electrically stimulated through intact enamel with non-painful stimuli. For stimulation and registration we used Xltek Protektor 32 system, software EPWorks, version 5.0 (Natus Medical Incorporated, Oakville, ON, Canada). The experiment consisted of two testing sessions. Five recordings were performed in each session. The first test session was before, and the second was 45 minutes after administration of a single dose of the ibuprofen (400 mg), bromazepam (1.5 mg) or placebo. Results. The results of the present study exhibit that both ibuprofen and bromazepam significantly increased all the latencies; ibuprofen decreased amplitudes of all the waves except the first one (p 0.05). Additionally, there were no significant differences in influence on TPEPs between bromazepam and ibuprofen (p > 0.05). Conclusion. Our study showed that both bromazepam and ibuprofen had the same influence on TPEPs after non-painful stimuli. That indicates that anxiolytic dose of bromazepam affects neurotransmission in the same manner as non-opioid analgesics ibuprofen.
Ključne reči:
Analgesic; Anxiolytic; Non-painful stimulus; Somatosensory evoked potentialsIzvor:
Srpski arhiv za celokupno lekarstvo, 2022, 150, 5-6, 267-273Finansiranje / projekti:
- Ministry of Education, Science and Technological Development, Republic of Serbia (Grant No. 34021)
DOI: 10.2298/SARH220131047V
ISSN: 0370-8179
WoS: 000830701100003
Scopus: 2-s2.0-85133688452
URI
http://www.doiserbia.nb.rs/Article.aspx?ID=0370-81792200047Vhttp://radar.ibiss.bg.ac.rs/handle/123456789/5077