Beneficial effects of probiotic supplementation on glucose and triglycerides in a mouse model of metabolic syndrome
2022
Аутори:
Zavišić, GordanaRistić, Slavica
Rikalović, Milena
Petković, Branka
Janković, Drina
Vukadinović, Aleksandar
Petričević, Saša
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
The present study aimed to examine the effect of Lactobacillus rhamnosus Rosell 11 and Lactobacillus helveticus Rosell 52 on glucose (blood level and tolerance), lipids (cholesterol and triglycerides), transaminases (AST and ALT), ALP, urea, and creatinine, along with body weight, food intake, liquid consumption, and gross pathology in a mouse model of metabolic syndrome. Male C57BL/6J mice were fed a high-fat high-sucrose diet and treated by oral gavage with a probiotic mixture in three different concentrations (107, 108, and 109 CFU/mL) once daily for 2 months. Probiotic supplementation, particularly at a concentration of 109 CFU, significantly decreased blood glucose and serum triglyceride levels, improved glucose tolerance, and promoted body weight loss in mice fed a high-fat high-sucrose diet. According to the obtained results, probiotic supplementation is useful for controlling glucose and triglyceride levels and could be used as an adjunctive therapeutic approach in patients with metabolic syndrome. © 2022
Кључне речи:
Biochemical parameters; Lactobacillus spp; Metabolic syndromeИзвор:
Journal of Functional Foods, 2022, 95, 105167-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
DOI: 10.1016/j.jff.2022.105167
ISSN: 1756-4646
WoS: 000863764500004
Scopus: 2-s2.0-85134990526
URI
https://linkinghub.elsevier.com/retrieve/pii/S1756464622002377http://radar.ibiss.bg.ac.rs/handle/123456789/5091