Pituitary gonadotroph-specific patterns of gene expression and hormone secretion.
2022
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
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© 2022 Elsevier B.V.
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Pituitary gonadotrophs play a key role in reproductive functions by secreting luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The LH secretory activity of gonadotroph is controlled by hypothalamic gonadotropin-releasing hormone (GnRH) via GnRH receptors and is accompanied by only minor effects on high basal Lhb gene expression. The secretory profiles of GnRH and LH are highly synchronized, with the latter reflecting a depletion of prestored LH in secretory vesicles by regulated exocytosis. In contrast, FSH is predominantly released by constitutive exocytosis, and secretory activity reflects the kinetics of Fshb gene expression controlled by GnRH, activin, and inhibin. Here is a review of recent data to improve the understanding of multiple patterns of gonadotroph gene expression and hormone secretion.
Ključne reči:
FSH; GnRH; LH; activin; gonadotrophs; inhibin; pituitaryIzvor:
Current Opinion in Pharmacology, 2022, 66, 102274-Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development , grant number: Z01 HD000195-25
DOI: 10.1016/j.coph.2022.102274
ISSN: 1471-4892
PubMed: 35994915
WoS: 00084815490000
Scopus: 2-s2.0-85136235223
URI
https://linkinghub.elsevier.com/retrieve/pii/S1471489222001011http://www.ncbi.nlm.nih.gov/pubmed/35994915
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9509429
http://radar.ibiss.bg.ac.rs/handle/123456789/5105