Cerebral hypoperfusion and progesterone treatment alter parameters of oxidative stress and antioxidant defence in male rats
2021
Authors:
Guševac Stojanović, IvanaTodorović, Ana
Pejić, Snežana
Tatalović, Nikola
Blagojević, Duško
Martinović, Jelena
Grković, Ivana
Mitrović, Nataša
Zarić, Marina
Drakulić, Dunja
Contributors
Čupić, ŽeljkoAnić, Slobodan
Document Type:
Conference object (Published version)
,
© 2021 by the Society of Physical Chemists of Serbia
Metadata
Show full item recordAbstract:
Numerous natural compounds, like progesterone (P4), a sex steroid hormone, are highlighted as promising agents for treatment of different disorders including prolonged disturbance of blood flow. However, its action on several oxidative stress markers (pro/antioxidant balance, products of lipid peroxidation and phosphatidylcholine to lysophosphatidylcholine intensity ratio) and one of the major components of antioxidant system, superoxide dismutase in rat prefrontal cortex (PFC) following permanent bilateral occlusion of common carotid arteries (2VO) is not completely investigated. According to the obtained results, levels of investigated oxidative stress markers and SOD activity were altered in 2VO animals treated with vehicle, while P4 treatment returned them to control values. Overall, presented data indicate that P4 might manifest antioxidative features in PFC of 2VO rats.
Keywords:
superoxide dismutase; prefrontal cortex; cerebrovascular insufficiency; carotid arteries; lipid peroxidationFunding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200017 (University of Belgrade, Institute of Nuclear Sciences 'Vinča', Belgrade-Vinča) (RS-MESTD-inst-2020-200017)
In:
- Čupić Ž, Anić S, editors. Proceeding: 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry: Physical Chemistry 2021: the Conference is dedicated to the 30th Anniversary of the founding of the Society of Physical Chemists of Serbia and 100th Anniversary of Bray-Liebhafsky reaction. Vol. 1; 2021 Sep 20-24; Belgrade, Serbia. Belgrade: Society of Physical Chemists of Serbia; 2021. p. 25-32.