Altruistic behavior of the cells – the seed of tumor progression and new terapeutic platform
2022
Тип документа:
Конференцијски прилог (Објављена верзија)
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© 2022 by the Serbian Society for Immunology, Molecular Oncology and Regenerative Medicine
Метаподаци
Приказ свих података о документуАпстракт:
The impact of the technology is a hallmark of a new era in molecular medicine, but,
paradoxically, it has not resulted in improved understanding of numerous degenerative/
proliferative diseases. Built on such a platform, highly specific oncotherapy aimed at the
malignant phenotype, or constituents of the tumor microenvironment from stromal to
endothelial and immune-infiltrating cells, was supposed to bring a revolutionary turn in
treatment. Instead, inadequate achievements and unclear correlations between individual
response to treatment and expression of relevant molecules in tumor tissue remind
us that, despite all biotechnological advances, understanding of disease pathology is still
very limited, while breaking down biological systems into molecular dimensions has
obscured meaning and functionality of the whole. This primarily refers to high-grade
tumors characterized by a fraction of low-differentiated cells, significant heterogeneity
of cell phenotypes and aggressive characteristics of the tumor microenvironment. As
the criterion of low general toxicity, which essentially represented the most important
advantage of molecular therapies and the main motive in their creation, is not satisfied,
the treatment often ends with the choice of non-selective chemotherapy or radiotherapy.
The limited success of aggressive treatments in advanced malignancies is closely
related to tumor repopulation in response to such treatments. This effect brought to
the surface a sophisticated communication network within the tumor tissue, revealing
intense contacts between vital and dying cells, which are profiled as the most important
stimulus in maintaining the continuity of life of the tumor mass. The possibilities of
getting out of this loop and leaving the vicious circle of death and division in the tumor,
as well as the potential of plants to stimulate the process of establishing new biological
balance and improve the effects of current therapy, will be discussed in this study.
Кључне речи:
cancer; therapy; cell death; differentiation; naturally occurring compoundsФинансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
- Молекуларни механизми физиолошке и фармаколошке контроле инфламације и канцера (RS-MESTD-Basic Research (BR or ON)-173013)
У:
- Arsenijević N, editor. Abstract Book: First Serbian molecular medicine congress; 2022 Jun 16-18; Foča, Bosnia and Herzegovina. Serbian Society for Immunology, Molecular Oncology and Regenerative Medicine; 2022. p. 132-3.