Next generation of fullerol derivate in melanoma cell reprogram
2022
Preuzimanje 🢃
Autori:
Maksimović-Ivanić, DanijelaMijatović, Sanja
Koruga, Đuro
Ostala autorstva
Arsenijević, NebojšaTip dokumenta:
Konferencijski prilog (Objavljena verzija)
,
© 2022 by the Serbian Society for Immunology, Molecular Oncology and Regenerative Medicine
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Nanotechnology, as a field of research related to the manifestation of special physicochemical
properties and behavior of materials in nanoscale, has experienced significant
progress in recent decades. It has led to the development of a distinct area - nanomedicine,
where nanomaterials find a place in the prevention, monitoring, diagnosis and
treatment of various diseases. Some types of nanomaterials show high efficacy in the
elimination of tumor cells and have already undergone clinical trials. Fullerene is the
third allotropic modification of carbon beside graphite and diamond. It is characterized
by an icosahedral molecular crystal structure with 12 pentagons and a variable
number of hexagons. The low solubility of fullerenes in polar solvents limited potential
applications in biomedicine and served as a platform for the development of a range of
compounds with better solubility and significantly improved properties. Among them,
polyhydroxylated fullerenes-fullerols stand out; with spectrum of biological activities
that attracts the attention of numerous researchers. In our study, the potential of a new
fullerol derivate (3HFWC) to inhibit the growth of melanoma cells of different origins
and invasiveness, in conjunction with hyperpolarized light, was examined. Suppression
of melanoma cell growth was a consequence of the loss of division potential, triggered
cellular senescence, and intensified melanocytic differentiation. In the syngeneic mouse
model, the combined action of 3HFWC and hyperpolarized light significantly inhibited
melanoma growth as a consequence of direct action on tumor cells but also modulation
of the pro/anti-tumor immune response. The complex mechanism of action that combines
the phenotypic transformation of melanoma cells and the effects on the immune
system makes hyper-hydroxylated fullerene worth further research.
Ključne reči:
melanoma; fullerol derivate; hyperpolarized light; senescence; differentiationFinansiranje / projekti:
- Zepter International Company (grant number 01-646)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
U:
- Arsenijević N, editor. Abstract Book: First Serbian molecular medicine congress; 2022 Jun 16-18; Foča, Bosnia and Herzegovina. Serbian Society for Immunology, Molecular Oncology and Regenerative Medicine; 2022. p. 37-8.