The effect of the duration of dietary restriction on insulin signaling pathway in the hippocampus of male Wistar rats
2022
Autori:
Simeunović, ValentinaMladenović, Aleksandra
Milanović, Desanka
Prvulović, Milica
Jović, Milena
Sokanović, Srđan
Todorović, Smilja
Tip dokumenta:
Konferencijski prilog (Objavljena verzija)
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© 2022 by the Federation of European Biochemical Societies
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
It has been shown that insulin has an important role in many processes in the brain, like upholding the nutritional homeostasis in the hypothalamus and synaptic plasticity
in the hippocampus. Insulin exerts its effects by acting through the insulin signaling pathway. During aging, chronic activation of this pathway can occur, leading to insulin
resistance, which is in the basis of many neurodegenerative diseases. Numerous environmental factors, such as dietary restriction (DR), can postpone and / or slow
down many of the agerelated processes. It is assumed that DR exerts its effect on insulin resistance through the insulin signaling pathway.
In this experiment we studied the effect of 40% DR (60% of ad libitum daily intake) on the expression of insulin, as well as on the amount of total (IRβ) and active
(pIRβ) form of insulin receptor in the hippocampus of male Wistar rats. We examined the effect of three different types of DR: DR1, which started at 6 months of age
and lasted up to 18 and 24 months, DR2, which lasted 6 months (1218 months and 1824 months of age), and DR3, which lasted 3 months (1518 months and 2124
months of age).
Our results showed that longterm DR1 led to a decrease in activity of insulin signaling pathway in the hippocampus of both 18 and 24monthold male Wistar rats,
which can further play a role in the prevention of neurodegenerative diseases.
Ključne reči:
Ageing; Insulin; HippocampusU:
- Book of Abstracts: Joint IUBMB/FEBS Advanced Lecture Course: Molecular targets for anti-aging interventions; 2022 Sep 26 - Oct 1; Spetses Island, Greece. Federation of European Biochemical Societies; 2022.