Dietary restriction as an antiaging intervention
2022
Autori:
Todorović, SmiljaPrvulović, Milica
Milanović, Desanka
Sokanović, Srđan
Vukojević, Anđela
Simeunović, Valentina
Kanazir, Selma
Mladenović, Aleksandra
Tip dokumenta:
Konferencijski prilog (Objavljena verzija)
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© 2022 by the Federation of European Biochemical Societies
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
Dietary restriction (DR) is the oldest and the most investigated antiaging intervention. Since the famous McCay's study that showed that the restriction of calories
without malnutrition prolongs mean and maximal lifespan in rats, thousands of papers demonstrated numerous beneficial effects of DR. DR is most famous for its proven
capability to prolong life span, but what we know today is that DR prevents agerelated diabetes, it decreases both incidence and progression of the different forms of
cancer, protects from cardiovascular diseases, delays osteoporosis and sarcopenia. Its effects on the nervous system include preserved cognition, delayed brain atrophy,
and protection from various neurodegenerative diseases.
By applying longterm dietary restrictions from the adulthood of male and female Wistar rats we demonstrated several beneficial outcomes. DR increased the level of
synaptic plasticity markers and neurotrophic factors in the rat cortex and hippocampus and preserved brain cholesterol homeostasis during aging. It also suppressed
apoptotic cell deaths after cortical injury and restored agerelated impaired glucocorticoid receptor (GR) signalling in the brain. DR changed the expression of genes
involved in AD pathology and suppressed microglial activation following cortical injury. However, recently we have been shown that the outcome of DR is highly
dependent on the onset and duration. Namely, we demonstrated that short–term DR with a lateonset could have unfavorable effects on cognitive performances, anxiety
level, and frailty in Wistar rats. In addition, DR could have a negative impact when introduced to transgenic AD animals. The results of our studies impose great caution
when introducing CR to humans. To achieve its favorable effect DR should be introduced in humans up to the middle age.
Ključne reči:
Ageing; Dietary restrictionU:
- Book of Abstracts: Joint IUBMB/FEBS Advanced Lecture Course: Molecular targets for anti-aging interventions; 2022 Sep 26 - Oct 1; Spetses Island, Greece. Federation of European Biochemical Societies; 2022.