Calorie restriction changes long-term and short-term memory in rats in an onset-, duration- and sex-dependent manner
2022
Authors:
Prvulović, MilicaTodorović, Smilja
Milanović, Desanka
Vukojević, Anđela
Simeunović, Valentina
Jović, Milena
Sokanović, Srđan
Mladenović, Aleksandra
Document Type:
Conference object (Published version)
,
© 2022 by the Federation of European Biochemical Societies
Metadata
Show full item recordAbstract:
Calorie restriction (CR) is known as a potent intervention to prolong lifespan and healthspan. However, in recent studies it was shown that its effect is not universally
beneficial, but it can vary from protective to detrimental depending on age when implemented and its duration. Herein, we tried to examine the effect of CR on shortterm
and longterm memory.
Ad libitum (AL) fed animals were used as controls. Wistar rats of different age (adult, middleaged and aged) were exposed to CR (60% of AL), to examine
the effect of earlyonset CR (EOCR) and lateonset CR (LOCR). Novel object recognition test (NORT) was used to assess shortterm (STM) and longterm memory
(LTM) performance.
Different pattern of changes was observed in males and females. While preserved memory was only measured in young AL males, in females both EOCR and LOCR
managed to preserve STM till 18 months of age, while LTM was preserved only with EOCR. In 24monthold females LOCR failed to preserve memory and even
worsened STM and LTM performance in comparison to the age matching AL controls, while in males neither EO nor LOCR had effect on memory performance.
EOCR succeeded to preserve STM and LTM in females, but till certain point in life. LOCR however seemed to have diametrically different effect depending on whether
it was implemented at middle age or old age. Memory performance of male rats in NORT seems to be insensitive to CR treatments, since only young animals had ability
to discriminate novel from old object.
Keywords:
Ageing; Calorie restriction; SexIn:
- Book of Abstracts: Joint IUBMB/FEBS Advanced Lecture Course: Molecular targets for anti-aging interventions; 2022 Sep 26 - Oct 1; Spetses Island, Greece. Federation of European Biochemical Societies; 2022.