Frailty: a way to measure aging
2022
Аутори:
Mladenović, AleksandraPrvulović, Milica
Jović, Milena
Simeunović, Valentina
Sokanović, Srđan
Vukojević, Anđela
Todorović, Smilja
Тип документа:
Конференцијски прилог (Објављена верзија)
,
© 2022 by the Federation of European Biochemical Societies
Метаподаци
Приказ свих података о документуАпстракт:
Frailty is a multidimensional syndrome in aging, allowing us the identification of the most vulnerable subset of older
adults. In the past few decades, medium life expectancy is increased without an appropriate increase of healthspan.
This phenomenon refers to an increased life expectancy without a proper increase of healthspan, the period of life
during which the organism is healthy and free of serious disease. Since healthspan is declining, there are more
individuals with morbidities and consequently an increasing number of frail individuals. When an individual is frail,
even a minor complication can create a chain of events that can give a rise to a disability or even death.
Nevertheless, there are old individuals who are not frail, so being old does not necessarily mean being frail. That is
why the concept of frailty was created, to explain the heterogeneity in clinical outcomes between older patients, so it
can be determined who is more likely to fall into the longevity trap.
The origin of frailty is based on the combination of genetic, biological, physical, psychological, social and
environmental factors3
. It is important to keep in mind that frailty is a dynamic condition, and it is potentially
reversible so the treatments, such as calorie restriction, can increase lifespan and concomitantly reduce age-related
disease5
. Optimal aging would then depend on conditions that both promote long life and compress morbidity to
achieve greater healthspan. Model organisms have been at the forefront in the aging research, giving us a wealth of
information regarding different pathways to regulate aging. That is the reason why in the past decade, an effort was
made to link the biology of aging with frailty in aging animal models. To achieve that, two major frailty models,
“Fried frailty phenotype” and “Rockwood frailty index” have been adapted and validated in animals.
Кључне речи:
Frailty; AgeingУ:
- Book of Abstracts: Joint IUBMB/FEBS Advanced Lecture Course: Molecular targets for anti-aging interventions; 2022 Sep 26 - Oct 1; Spetses Island, Greece. Federation of European Biochemical Societies; 2022.