Plant derived sweeteners promote virulence of pathogenic bacteria
2022
Тип документа:
Конференцијски прилог (Објављена верзија)
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© 2022 by the Serbian Plant Physiology Society
Метаподаци
Приказ свих података о документуАпстракт:
Different sweeteners are used in diet but not much is known about different aspects of human
health that they can affect. Consequently, the influence of sweeteners used in nutrition on the development of resistance and virulence of microorganisms (species of the genus Candida, Pseudomonas, Staphylococcus) were examined. Three plant-derived sweeteners were selected: demerara
sugar (from sugar cane), stevia (isolated from Stevia rebaudiana), and coconut sugar (from coconut
palm). An increase in the minimum inhibitory concentration of commercial antibiotics in the presence of studied sweeteners has been observed. Also, an increase in the biofilm production ability
in the presence of sweeteners is noticed for all the species except C. albicans: demerara sugar (P.
aeruginosa 528%, S. aureus 262%, C. albicans 64%), stevia (P. aeruginosa 140%, S. aureus 180%, C.
albicans 79%), coconut sugar (P. aeruginosa 408%, S. aureus 307%, C. albicans 57%) as compared
to the untreated control biofilm production (100%). Exposure of P. aeruginosa to demerara sugar
induced increase in expression of virulence associated lasI and lasR genes. On the other hand, in
C. albicans no significant increase in formation of hyphae in the presence of sweeteners has been
observed (demerara sugar induced hyphae to 113%, stevia 72%, coconut sugar 13%, compared to
the untreated control). Plant derived sweeteners increase virulence of bacterial species, but not C.
albicans. Higher awareness and further research is needed in order to highlight the effects plant
derived sweeteners could induce in pathogenic bacteria and to provide novel tools to reduce this
negative aspect.
Кључне речи:
sweeteners; virulence factors; biofilm; microorganismsФинансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
У:
- Milutinović M, editor. Book of Abstracts: 4th International Conference on Plant Biology and 23rd SPPS Meeting; 2022 6-8; Belgrade, Serbia. Belgrade: Serbian Plant Physiology Society; 2022. p. 116.