Experimental life history evolution results in sex-specific evolution of gene expression in seed beetles
2023
Autori:
Immonen, ElinaSayadi, Ahmed
Stojković, Biljana
Savković, Uroš
Đorđević, Mirko
Liljestrand-Rönn, Johanna
Wiberg, Axel
Arnqvist, Göran
Tip dokumenta:
Članak u časopisu (Objavljena verzija)
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© The Author(s) 2022. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution
Metapodaci
Prikaz svih podataka o dokumentuApstrakt:
The patterns of reproductive timing and senescence vary within and across species owing to differences in reproductive strategies, but our understanding of the molecular underpinnings of such variation is incomplete. This is perhaps particularly true for sex differences. We investigated the evolution of sex-specific gene expression associated with life history divergence in replicated populations of the seed beetle Acanthoscelides obtectus, experimentally evolving under (E)arly or (L)ate life reproduction for >200 generations which has resulted in strongly divergent life histories. We detected 1,646 genes that were differentially expressed in E and L lines, consistent with a highly polygenic basis of life history evolution. Only 30% of differentially expressed genes were similarly affected in males and females. The evolution of long life was associated with significantly reduced sex differences in expression, especially in non-reproductive tissues. The expression differences were overall more pronounced in females, in accordance with their greater phenotypic divergence in lifespan. Functional enrichment analysis revealed differences between E and L beetles in gene categories previously implicated in aging, such as mitochondrial function and defense response. The results show that divergent life history evolution can be associated with profound changes in gene expression that alter the transcriptome in a sex-specific way, highlighting the importance of understanding the mechanisms of aging in each sex.
Ključne reči:
longevity; experimental evolution; RNA-seq; aging; life history evolution; sex biasIzvor:
Genome Biology and Evolution, 2023, 15, 1, evac177-Finansiranje / projekti:
- Swedish Research Council VR (no. 2019-03611 to G.A.)
- Swedish Research Council FORMAS (no. 2018-00705 to G.A.)
- Swedish Research Council VR (no. 2019-05038 to E.I.)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200007 (Univerzitet u Beogradu, Institut za biološka istraživanja 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- GENCON - The evolutionary implications of genetic conflict (EU-FP7-294333)