Path to healthy aging: assessment of different dietary restriction protocols through behavioral and frailty measurements
2022
Authors:
Todorović, SmiljaMladenović, Aleksandra
Prvulović, Milica
Milanović, Desanka
Simeunović, Valentina
Jović, Milena
Sokanović, Srđan
Vukojević, Anđela
Document Type:
Conference object (Published version)
,
© 2022 by the Federation of European Biochemical Societies
Metadata
Show full item recordAbstract:
Aging is an inevitable, complex and dynamic process of natural change, leading to deleterious agerelated modifications. Still, the aging process can be modified by
lifestyle interventions, like dietary restriction (DR). Although DR is a proven experimental paradigm for lifespan and healthspan extension, the impact of the type, onset
and duration of DR is still debatable. In order to test different dietary types, we used frailty as a tool for detecting DR outcomes throughout aging. In this report, we
describe that different dietary protocols have various impact on agerelated behavioral parameters and frailty status.
We exposed male Wistar rats of various age to ad libitum (AL) or DR (60% of AL daily intake) feeding regimens with different onsets. The effect of DR on locomotor
activity, memory and learning was examined in 12, 18 and 24monthold animals using open field (OF) and Y maze test. We used behavioral data to create unique
frailty score (FS) and determine frailty status in those animals.
Our results indicated that various durations and onsets of DR can alter the course of aging, with the lifelong DR responsible for the most profound effect. Shorter
duration/later onset of DR had minor or in some cases even detrimental impact on behavior and frailty during aging.
Keywords:
Aging; Dietary restriction; FrailtyFunding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
In:
- Book of Abstracts: Joint IUBMB/FEBS Advanced Lecture Course: Molecular targets for anti-aging interventions; 2022 Sep 26 - Oct 1; Spetses Island, Greece. Federation of European Biochemical Societies; 2022.