Experimental and In Silico Evaluation of New Heteroaryl Benzothiazole Derivatives as Antimicrobial Agents
2022
Authors:
Zubenko, AlexanderKartsev, Victor
Petrou, Anthi
Geronikaki, Athina
Ivanov, Marija
Glamočlija, Jasmina
Soković, Marina
Divaeva, Lyudmila
Morkovnik, Anatolii
Klimenko, Alexander
Document Type:
Article (Published version)
Metadata
Show full item recordAbstract:
In this manuscript, we describe the design, preparation, and studies of antimicrobial activity of a series of novel heteroarylated benzothiazoles. A molecular hybridization approach was used for the designing compounds. The in vitro evaluation exposed that these compounds showed moderate antibacterial activity. Compound 2j was found to be the most potent (MIC/MBC at 0.23-0.94 mg/mL and 0.47-1.88 mg/mL) On the other hand, compounds showed good antifungal activity (MIC/MFC at 0.06-0.47 and 0.11-0.94 mg/mL respectively) with 2d being the most active one. The docking studies revealed that inhibition of E. coli MurB and 14-lanosterol demethylase probably represent the mechanism of antibacterial and antifungal activities.
Keywords:
antibacterial; antifungal; antimicrobial; heteroarylated benzothiazole; molecular dockingSource:
Antibiotics, 2022, 11, 11, 1654-Funding / projects:
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200007 (University of Belgrade, Institute for Biological Research 'Siniša Stanković') (RS-MESTD-inst-2020-200007)
- Ministry of Science and Higher Education of the Russian Federation (Southern Federal University, 2020, project FENW-2020-0031)
- Fundamental Scientific Research of the State Academies of Sciences for 2014–2021 (grant no. 0710-2019-0044)
DOI: 10.3390/antibiotics11111654
ISSN: 2079-6382
PubMed: 36421298
WoS: 000930738700001
Scopus: 2-s2.0-85145741255
URI
https://www.mdpi.com/2079-6382/11/11/1654http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9686863
http://radar.ibiss.bg.ac.rs/handle/123456789/5399