Experimental and In Silico Evaluation of New Heteroaryl Benzothiazole Derivatives as Antimicrobial Agents
2022
Аутори:
Zubenko, AlexanderKartsev, Victor
Petrou, Anthi
Geronikaki, Athina
Ivanov, Marija
Glamočlija, Jasmina
Soković, Marina
Divaeva, Lyudmila
Morkovnik, Anatolii
Klimenko, Alexander
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
In this manuscript, we describe the design, preparation, and studies of antimicrobial activity of a series of novel heteroarylated benzothiazoles. A molecular hybridization approach was used for the designing compounds. The in vitro evaluation exposed that these compounds showed moderate antibacterial activity. Compound 2j was found to be the most potent (MIC/MBC at 0.23-0.94 mg/mL and 0.47-1.88 mg/mL) On the other hand, compounds showed good antifungal activity (MIC/MFC at 0.06-0.47 and 0.11-0.94 mg/mL respectively) with 2d being the most active one. The docking studies revealed that inhibition of E. coli MurB and 14-lanosterol demethylase probably represent the mechanism of antibacterial and antifungal activities.
Кључне речи:
antibacterial; antifungal; antimicrobial; heteroarylated benzothiazole; molecular dockingИзвор:
Antibiotics, 2022, 11, 11, 1654-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
- Ministry of Science and Higher Education of the Russian Federation (Southern Federal University, 2020, project FENW-2020-0031)
- Fundamental Scientific Research of the State Academies of Sciences for 2014–2021 (grant no. 0710-2019-0044)
DOI: 10.3390/antibiotics11111654
ISSN: 2079-6382
PubMed: 36421298
WoS: 000930738700001
Scopus: 2-s2.0-85145741255
URI
https://www.mdpi.com/2079-6382/11/11/1654http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9686863
http://radar.ibiss.bg.ac.rs/handle/123456789/5399