Maternal Dexamethasone Exposure Induces Sex-Specific Changes in Histomorphology and Redox Homeostasis of Rat Placenta
2023
Аутори:
Trifunović, SvetlanaŠošić-Jurjević, Branka
Ristić, Nataša
Nestorović, Nataša
Filipović, Branko
Stevanović, Ivana
Begović-Kuprešanin, Vesna
Manojlović-Stojanoski, Milica
Тип документа:
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт:
As the mediator between the mother and fetus, the placenta allows the most appropriate environment and optimal fetal growth. The placenta of one sex sometimes has a greater ability over the other to respond to and protect against possible maternal insults. Here, we characterized sex differences in the placenta's morphological features and antioxidant status following dexamethasone (Dx) exposure. Pregnant rats were exposed to Dx or saline. The placenta was histologically and stereologically analyzed. The activity of the antioxidant enzymes, lipid peroxides (TBARS), superoxide anion and nitric oxide (NO) was measured. The decrease in placental zone volumes was more pronounced (p < 0.05) in female placentas. The volume density of PCNA-immunopositive nuclei was reduced (p < 0.05) in both sexes. The reduced (p < 0.05) antioxidant enzyme activities, enhanced TBARS and NO concentration indicate that Dx exposure triggered oxidative stress in the placenta of both fetal sexes, albeit stronger in the placenta of female fetuses. In conclusion, maternal Dx treatment reduced the size and volume of placental zones, altered placental histomorphology, decreased cell proliferation and triggered oxidative stress; however, the placentas of female fetuses exerted more significant responses to the treatment effects. The reduced placental size most probably reduced the transport of nutrients and oxygen, thus resulting in the reduced weight of fetuses, similar in both sexes. The lesser ability of the male placenta to detect and react to maternal exposure to environmental challenges may lead to long-standing health effects.
Кључне речи:
dexamethasone; histology; oxidative stress; placenta; pregnancy; ratИзвор:
International Journal of Molecular Sciences, 2023, 24, 1, 540-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200007 (Универзитет у Београду, Институт за биолошка истраживања 'Синиша Станковић') (RS-MESTD-inst-2020-200007)
- Medical Faculty of Military Medical Academy University of Defense, Grant MFVMA/04/19-21.
DOI: 10.3390/ijms24010540
ISSN: 1422-0067
PubMed: 36613982
WoS: 000908509300001
Scopus: 2-s2.0-85145965427
URI
https://www.mdpi.com/1422-0067/24/1/540http://www.ncbi.nlm.nih.gov/pubmed/36613982
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC9820254
http://radar.ibiss.bg.ac.rs/handle/123456789/5402